| BAKER BROS. ADVISORS LP | 42,912,904 | $1.1bn | 5.4% |
| BlackRock, Inc. | 22,515,173 | $569.6m | 0.0% |
| STATE STREET CORP | 9,076,212 | $229.6m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 8,838,450 | $223.6m | 0.0% |
| RTW INVESTMENTS, LP | 7,144,524 | $180.8m | 1.5% |
| VANGUARD CAPITAL MANAGEMENT LLC | 5,763,750 | $145.8m | 0.0% |
| DIMENSIONAL FUND ADVISORS LP | 3,694,988 | $93.5m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 3,358,129 | $85.0m | 0.0% |
| Palo Alto Investors LP | 2,864,096 | $72.5m | 10.0% |
| GOLDMAN SACHS GROUP INC | 2,580,115 | $65.3m | 0.0% |
| Qube Research & Technologies Ltd | 2,446,610 | $61.9m | 0.1% |
| Point72 Asset Management, L.P. | 2,433,168 | $61.6m | 0.1% |
| CITADEL ADVISORS LLC | 2,182,177 | $55.2m | 0.0% |
| Pictet Asset Management Holding SA | 1,983,198 | $50.1m | 0.0% |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 1,969,445 | $49.8m | 0.0% |
| MARSHALL WACE, LLP | 1,764,838 | $44.7m | 0.0% |
| D. E. Shaw & Co., Inc. | 1,697,937 | $43.0m | 0.0% |
| BRAIDWELL LP | 1,646,399 | $41.7m | 1.5% |
| NORGES BANK | 1,623,308 | $41.1m | 0.0% |
| Frazier Life Sciences Management, L.P. | 1,438,198 | $36.4m | 0.8% |
| NORTHERN TRUST CORP | 1,367,422 | $34.6m | 0.0% |
| Nuveen, LLC | 1,348,192 | $34.1m | 0.0% |
| Artisan Partners Limited Partnership | 1,325,134 | $33.5m | 0.1% |
| BANK OF AMERICA CORP /DE/ | 1,300,385 | $32.9m | 0.0% |
| RENAISSANCE TECHNOLOGIES LLC | 1,282,596 | $32.4m | 0.0% |