| Knoll Capital Management, LLC | 5,475,516 | $11.7m | 6.5% |
| AQR CAPITAL MANAGEMENT LLC | 3,751,558 | $8.0m | 0.0% |
| KINGDON CAPITAL MANAGEMENT, L.L.C. | 2,652,315 | $5.6m | 0.6% |
| VANGUARD CAPITAL MANAGEMENT LLC | 2,361,796 | $5.0m | 0.0% |
| D. E. Shaw & Co., Inc. | 1,940,338 | $4.1m | 0.0% |
| MARSHALL WACE, LLP | 1,506,974 | $3.2m | 0.0% |
| 683 Capital Management, LLC | 1,450,000 | $3.1m | 0.2% |
| JANE STREET GROUP, LLC | 1,375,115 | $2.9m | 0.0% |
| BlackRock, Inc. | 1,257,243 | $2.7m | 0.0% |
| Qube Research & Technologies Ltd | 1,128,803 | $2.4m | 0.0% |
| ACADIAN ASSET MANAGEMENT LLC | 1,063,793 | $2.3m | 0.0% |
| ARDSLEY ADVISORY PARTNERS LP | 975,000 | $2.1m | 0.2% |
| RENAISSANCE TECHNOLOGIES LLC | 882,000 | $1.9m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 794,863 | $1.7m | 0.0% |
| GOLDMAN SACHS GROUP INC | 725,444 | $1.5m | 0.0% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 646,840 | $1.4m | 0.0% |
| MORGAN STANLEY | 608,321 | $1.3m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 596,029 | $1.3m | 0.0% |
| DIMENSIONAL FUND ADVISORS LP | 529,083 | $1.1m | 0.0% |
| GSA CAPITAL PARTNERS LLP | 472,564 | $1.0m | 0.1% |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 421,178 | $897,109 | 0.0% |
| CANTOR FITZGERALD, L. P. | 400,000 | $852,000 | 0.0% |
| CITADEL ADVISORS LLC | 379,144 | $807,576 | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 360,350 | $767,546 | 0.0% |
| UBS Group AG | 301,940 | $643,132 | 0.0% |