| BlackRock, Inc. | 20,385,284 | $62.0m | 0.0% |
| Deep Track Capital, LP | 19,250,000 | $58.5m | 0.9% |
| STATE STREET CORP | 12,098,540 | $36.8m | 0.0% |
| TCG Crossover Management, LLC | 10,000,000 | $30.4m | 0.7% |
| VANGUARD CAPITAL MANAGEMENT LLC | 8,177,752 | $24.9m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 7,330,265 | $22.3m | 0.0% |
| MARSHALL WACE, LLP | 6,841,055 | $20.8m | 0.0% |
| VIKING GLOBAL INVESTORS LP | 6,700,000 | $20.4m | 0.1% |
| RA CAPITAL MANAGEMENT, L.P. | 6,500,000 | $19.8m | 0.2% |
| GEODE CAPITAL MANAGEMENT, LLC | 5,011,314 | $15.2m | 0.0% |
| Woodline Partners LP | 3,400,312 | $10.3m | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 3,309,122 | $10.1m | 0.0% |
| Nantahala Capital Management, LLC | 3,000,000 | $9.1m | 0.2% |
| Trails Edge Capital Partners, LP | 2,660,000 | $8.1m | 1.3% |
| Nuveen, LLC | 2,405,354 | $7.3m | 0.0% |
| TWO SIGMA INVESTMENTS, LP | 2,381,142 | $7.2m | 0.0% |
| GOLDMAN SACHS GROUP INC | 2,214,450 | $6.7m | 0.0% |
| GREAT POINT PARTNERS LLC | 1,741,232 | $5.3m | 1.0% |
| NORTHERN TRUST CORP | 1,599,226 | $4.9m | 0.0% |
| Weiss Asset Management LP | 1,530,803 | $4.7m | 0.0% |
| VANGUARD FIDUCIARY TRUST CO | 1,293,001 | $3.9m | 0.0% |
| Cormorant Asset Management, LP | 1,250,000 | $3.8m | 0.2% |
| AQR CAPITAL MANAGEMENT LLC | 1,220,949 | $3.7m | 0.0% |
| CITADEL ADVISORS LLC | 983,559 | $3.0m | 0.0% |
| UBS Group AG | 866,385 | $2.6m | 0.0% |