| FMR LLC | 16,727,909 | $300.4m | 0.0% |
| BlackRock, Inc. | 8,827,085 | $158.5m | 0.0% |
| PERCEPTIVE ADVISORS LLC | 8,334,882 | $149.7m | 2.2% |
| TCG Crossover Management, LLC | 6,243,812 | $112.1m | 2.7% |
| Commodore Capital LP | 5,650,000 | $101.5m | 6.0% |
| Jupiter Topco LLC | 5,236,102 | $94.0m | 0.0% |
| Saturn V Capital Management LP | 4,624,101 | $83.0m | 11.9% |
| VANGUARD CAPITAL MANAGEMENT LLC | 4,224,224 | $75.9m | 0.0% |
| MORGAN STANLEY | 3,130,808 | $56.2m | 0.0% |
| Driehaus Capital Management LLC | 3,036,970 | $54.5m | 0.3% |
| First Light Asset Management, LLC | 3,023,256 | $54.3m | 3.3% |
| FRANKLIN RESOURCES INC | 2,950,225 | $53.0m | 0.0% |
| GOLDMAN SACHS GROUP INC | 2,858,239 | $51.3m | 0.0% |
| STATE STREET CORP | 2,603,337 | $46.8m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 2,335,315 | $41.9m | 0.0% |
| JPMORGAN CHASE & CO | 1,863,650 | $34.9m | 0.0% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,900,000 | $34.1m | 0.0% |
| Siren, L.L.C. | 1,480,586 | $26.6m | 0.5% |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,327,536 | $23.8m | 0.3% |
| 683 Capital Management, LLC | 1,279,512 | $23.0m | 1.1% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 1,061,534 | $19.1m | 0.0% |
| Alyeska Investment Group, L.P. | 1,053,015 | $18.9m | 0.0% |
| Almitas Capital LLC | 974,881 | $17.5m | 4.3% |
| Nantahala Capital Management, LLC | 973,368 | $17.5m | 0.3% |
| DIMENSIONAL FUND ADVISORS LP | 902,463 | $16.2m | 0.0% |