| BlackRock, Inc. | 14,830,553 | $1.2bn | 0.0% |
| Avoro Capital Advisors LLC | 11,355,555 | $925.6m | 8.3% |
| FMR LLC | 8,039,804 | $655.3m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 6,351,355 | $517.7m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 6,110,953 | $498.1m | 0.0% |
| STATE STREET CORP | 5,694,640 | $464.2m | 0.0% |
| NORGES BANK | 3,896,536 | $317.6m | 0.0% |
| Invesco Ltd. | 3,883,976 | $316.6m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 3,530,612 | $298.8m | 0.0% |
| FRED ALGER MANAGEMENT, LLC | 3,301,919 | $269.1m | 0.9% |
| BAKER BROS. ADVISORS LP | 1,992,783 | $162.4m | 0.8% |
| Siren, L.L.C. | 1,715,476 | $139.8m | 2.8% |
| Vestal Point Capital, LP | 1,575,000 | $128.4m | 3.0% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,389,055 | $113.2m | 1.2% |
| FIRST TRUST ADVISORS LP | 1,352,918 | $110.3m | 0.1% |
| Driehaus Capital Management LLC | 1,350,556 | $110.1m | 0.6% |
| Jupiter Topco LLC | 1,221,596 | $99.6m | 0.0% |
| NORTHERN TRUST CORP | 1,192,868 | $97.2m | 0.0% |
| DIMENSIONAL FUND ADVISORS LP | 1,181,608 | $96.3m | 0.0% |
| GOLDMAN SACHS GROUP INC | 1,150,007 | $93.7m | 0.0% |
| BANK OF AMERICA CORP /DE/ | 1,139,810 | $92.9m | 0.0% |
| Hood River Capital Management LLC | 1,120,747 | $91.4m | 0.7% |
| Holocene Advisors, LP | 1,106,177 | $90.2m | 0.2% |
| MORGAN STANLEY | 1,084,835 | $88.4m | 0.0% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 964,479 | $78.6m | 0.0% |