| WELLINGTON MANAGEMENT GROUP LLP | 9,543,671 | $355.1m | 0.1% |
| BlackRock, Inc. | 7,002,530 | $260.6m | 0.0% |
| Kynam Capital Management, LP | 5,322,908 | $198.1m | 10.9% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 4,685,223 | $174.3m | 0.0% |
| STATE STREET CORP | 3,900,427 | $145.1m | 0.0% |
| FMR LLC | 3,722,888 | $138.5m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 3,464,831 | $128.9m | 0.0% |
| Deep Track Capital, LP | 2,939,151 | $109.4m | 1.6% |
| Logos Global Management LP | 2,100,000 | $78.1m | 3.4% |
| GEODE CAPITAL MANAGEMENT, LLC | 2,022,226 | $75.3m | 0.0% |
| Eversept Partners, LP | 1,785,941 | $66.5m | 3.4% |
| GOLDMAN SACHS GROUP INC | 1,615,343 | $60.1m | 0.0% |
| Assenagon Asset Management S.A. | 1,577,392 | $58.7m | 0.0% |
| Commodore Capital LP | 1,350,000 | $50.2m | 3.0% |
| Bellevue Group AG | 1,200,000 | $44.7m | 0.9% |
| BAKER BROS. ADVISORS LP | 1,182,611 | $44.0m | 0.2% |
| MILLENNIUM MANAGEMENT LLC | 1,170,787 | $43.6m | 0.0% |
| DIMENSIONAL FUND ADVISORS LP | 1,073,985 | $40.0m | 0.0% |
| AMERICAN CENTURY COMPANIES INC | 1,042,395 | $38.8m | 0.0% |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,037,000 | $38.6m | 0.5% |
| NOVO HOLDINGS A/S | 1,025,000 | $38.1m | 2.2% |
| Elmind Capital, LP | 990,000 | $36.8m | 9.3% |
| Driehaus Capital Management LLC | 989,442 | $36.8m | 0.2% |
| Fisher Asset Management, LLC | 985,677 | $36.7m | 0.0% |
| Pictet Asset Management Holding SA | 917,408 | $34.1m | 0.0% |