| BlackRock, Inc. | 11,232,834 | $528.4m | 0.0% |
| Avoro Capital Advisors LLC | 7,188,888 | $338.2m | 3.0% |
| Driehaus Capital Management LLC | 6,845,276 | $322.0m | 1.9% |
| Jupiter Topco LLC | 5,615,645 | $264.0m | 0.1% |
| Capital World Investors | 5,367,723 | $252.5m | 0.0% |
| FMR LLC | 4,752,921 | $223.6m | 0.0% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 4,652,032 | $218.8m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 3,644,813 | $171.5m | 0.0% |
| STATE STREET CORP | 3,065,390 | $144.2m | 0.0% |
| Capital International Investors | 2,963,410 | $139.4m | 0.0% |
| Octagon Capital Advisors LP | 2,950,000 | $138.8m | 12.5% |
| WELLINGTON MANAGEMENT GROUP LLP | 2,949,734 | $138.8m | 0.0% |
| Deep Track Capital, LP | 2,750,000 | $129.4m | 1.9% |
| Commodore Capital LP | 2,000,000 | $94.1m | 5.6% |
| GOLDMAN SACHS GROUP INC | 1,800,852 | $84.7m | 0.0% |
| CITADEL ADVISORS LLC | 1,688,587 | $79.4m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 1,648,426 | $77.5m | 0.0% |
| RA CAPITAL MANAGEMENT, L.P. | 1,500,000 | $70.6m | 0.6% |
| VANGUARD CAPITAL MANAGEMENT LLC | 1,486,454 | $69.9m | 0.0% |
| Siren, L.L.C. | 1,419,493 | $66.8m | 1.4% |
| MARSHALL WACE, LLP | 1,298,946 | $61.1m | 0.0% |
| NORTHERN TRUST CORP | 1,169,238 | $55.0m | 0.0% |
| AMERIPRISE FINANCIAL INC | 1,148,363 | $54.0m | 0.0% |
| Nuveen, LLC | 1,105,314 | $52.0m | 0.0% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,083,576 | $51.0m | 0.0% |