| T. Rowe Price Investment Management, Inc. | 30,912,287 | $686.6m | 0.5% |
| BlackRock, Inc. | 12,404,330 | $275.5m | 0.0% |
| Jupiter Topco LLC | 11,997,738 | $266.6m | 0.1% |
| FMR LLC | 11,207,000 | $248.9m | 0.0% |
| STATE STREET CORP | 7,458,263 | $165.6m | 0.0% |
| Orbis Allan Gray Ltd | 7,006,542 | $155.6m | 0.5% |
| Atlas Venture Life Science Advisors, LLC | 6,800,099 | $151.0m | 17.1% |
| VANGUARD CAPITAL MANAGEMENT LLC | 6,310,969 | $140.2m | 0.0% |
| TCG Crossover Management, LLC | 4,615,144 | $102.5m | 2.5% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 4,048,428 | $89.9m | 0.0% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,936,806 | $87.4m | 0.0% |
| FCPM III SERVICES B.V. | 3,848,256 | $85.5m | 11.4% |
| GEODE CAPITAL MANAGEMENT, LLC | 3,743,427 | $83.2m | 0.0% |
| Vestal Point Capital, LP | 3,375,000 | $75.0m | 1.8% |
| ORBIMED ADVISORS LLC | 3,235,684 | $71.9m | 1.3% |
| Frazier Life Sciences Management, L.P. | 3,153,082 | $70.0m | 1.5% |
| ARMISTICE CAPITAL, LLC | 3,087,226 | $68.6m | 0.8% |
| JPMORGAN CHASE & CO | 3,151,656 | $67.2m | 0.0% |
| PERCEPTIVE ADVISORS LLC | 2,689,235 | $59.7m | 0.9% |
| Logos Global Management LP | 2,550,000 | $56.6m | 2.4% |
| BANK OF AMERICA CORP /DE/ | 2,233,398 | $49.6m | 0.0% |
| Venrock Adviser, LLC | 2,173,913 | $48.3m | 1.5% |
| GOLDMAN SACHS GROUP INC | 2,157,195 | $47.9m | 0.0% |
| Siren, L.L.C. | 2,129,125 | $47.3m | 1.0% |
| FRANKLIN RESOURCES INC | 2,030,819 | $45.1m | 0.0% |