| ORBIMED ADVISORS LLC | 15,518,492 | $630.5m | 11.7% |
| Paradigm Biocapital Advisors LP | 10,215,455 | $415.1m | 7.8% |
| RA CAPITAL MANAGEMENT, L.P. | 8,392,730 | $341.0m | 3.0% |
| BlackRock, Inc. | 6,606,336 | $268.4m | 0.0% |
| Jupiter Topco LLC | 6,075,331 | $246.9m | 0.1% |
| FMR LLC | 5,489,135 | $223.0m | 0.0% |
| NOVO HOLDINGS A/S | 5,350,000 | $217.4m | 12.6% |
| Driehaus Capital Management LLC | 4,728,623 | $192.1m | 1.1% |
| PERCEPTIVE ADVISORS LLC | 4,373,974 | $177.7m | 2.7% |
| VANGUARD CAPITAL MANAGEMENT LLC | 3,860,670 | $156.9m | 0.0% |
| BAKER BROS. ADVISORS LP | 3,701,719 | $150.4m | 0.8% |
| Siren, L.L.C. | 3,184,629 | $129.4m | 2.6% |
| Cormorant Asset Management, LP | 2,510,000 | $102.0m | 5.2% |
| GEODE CAPITAL MANAGEMENT, LLC | 2,174,051 | $88.3m | 0.0% |
| Integral Health Asset Management, LLC | 2,000,000 | $81.3m | 3.2% |
| BRAIDWELL LP | 1,996,965 | $81.1m | 3.0% |
| MORGAN STANLEY | 1,948,597 | $79.2m | 0.0% |
| STATE STREET CORP | 1,827,927 | $74.3m | 0.0% |
| ALLIANCEBERNSTEIN L.P. | 2,119,024 | $66.7m | 0.0% |
| MPM BIOIMPACT LLC | 1,620,780 | $65.9m | 4.0% |
| BANK OF AMERICA CORP /DE/ | 1,558,260 | $63.3m | 0.0% |
| Qube Research & Technologies Ltd | 1,252,507 | $50.9m | 0.0% |
| DIMENSIONAL FUND ADVISORS LP | 1,139,726 | $46.3m | 0.0% |
| AMERICAN CENTURY COMPANIES INC | 1,127,078 | $45.8m | 0.0% |
| First Light Asset Management, LLC | 1,095,171 | $44.5m | 2.7% |