| BlackRock, Inc. | 4,737,519 | $211.3m | 0.0% |
| WELLINGTON MANAGEMENT GROUP LLP | 2,382,660 | $106.3m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 2,088,961 | $93.2m | 0.0% |
| Soleus Capital Management, L.P. | 1,931,436 | $86.2m | 3.0% |
| AQR CAPITAL MANAGEMENT LLC | 1,856,800 | $80.9m | 0.0% |
| Assenagon Asset Management S.A. | 1,728,790 | $77.1m | 0.0% |
| UBS Group AG | 1,645,511 | $73.4m | 0.0% |
| D. E. Shaw & Co., Inc. | 1,470,462 | $65.6m | 0.0% |
| NOMURA HOLDINGS INC | 1,369,410 | $61.1m | 0.1% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,296,862 | $57.9m | 0.6% |
| VANGUARD CAPITAL MANAGEMENT LLC | 1,270,928 | $56.7m | 0.0% |
| STATE STREET CORP | 1,206,494 | $53.8m | 0.0% |
| MORGAN STANLEY | 791,222 | $35.3m | 0.0% |
| Artisan Partners Limited Partnership | 732,323 | $32.7m | 0.1% |
| GEODE CAPITAL MANAGEMENT, LLC | 700,836 | $31.3m | 0.0% |
| BRAIDWELL LP | 677,570 | $30.2m | 1.1% |
| GOLDMAN SACHS GROUP INC | 645,858 | $28.8m | 0.0% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 546,020 | $24.4m | 0.0% |
| Nantahala Capital Management, LLC | 538,948 | $24.0m | 0.4% |
| CITADEL ADVISORS LLC | 506,334 | $22.6m | 0.0% |
| SG Americas Securities, LLC | 491,703 | $21.9m | 0.0% |
| BNP PARIBAS FINANCIAL MARKETS | 428,069 | $19.1m | 0.0% |
| RENAISSANCE TECHNOLOGIES LLC | 426,000 | $19.0m | 0.0% |
| ADAR1 Capital Management, LLC | 374,617 | $16.7m | 0.8% |
| Aberdeen Group plc | 358,968 | $16.0m | 0.0% |