| FMR LLC | 4,894,473 | $358.0m | 0.0% |
| BlackRock, Inc. | 2,467,899 | $180.5m | 0.0% |
| RA CAPITAL MANAGEMENT, L.P. | 2,450,221 | $179.2m | 1.6% |
| JPMORGAN CHASE & CO | 1,875,795 | $139.9m | 0.0% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,875,399 | $137.2m | 0.0% |
| WELLINGTON MANAGEMENT GROUP LLP | 1,741,351 | $127.4m | 0.0% |
| STATE STREET CORP | 1,648,836 | $120.6m | 0.0% |
| Vestal Point Capital, LP | 1,550,000 | $113.4m | 2.6% |
| Atlas Venture Life Science Advisors, LLC | 1,513,875 | $110.7m | 12.6% |
| VANGUARD CAPITAL MANAGEMENT LLC | 1,369,027 | $100.1m | 0.0% |
| Frazier Life Sciences Management, L.P. | 1,354,852 | $99.1m | 2.2% |
| TCG Crossover Management, LLC | 1,341,862 | $98.1m | 2.4% |
| BVF INC/IL | 1,153,612 | $84.4m | 2.2% |
| Woodline Partners LP | 958,281 | $70.1m | 0.2% |
| Siren, L.L.C. | 888,401 | $65.0m | 1.3% |
| Logos Global Management LP | 875,000 | $64.0m | 2.8% |
| Opaleye Management Inc. | 855,000 | $62.5m | 5.7% |
| GEODE CAPITAL MANAGEMENT, LLC | 789,724 | $57.8m | 0.0% |
| Assenagon Asset Management S.A. | 768,316 | $56.2m | 0.0% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 657,000 | $48.1m | 0.5% |
| DIMENSIONAL FUND ADVISORS LP | 569,018 | $41.6m | 0.0% |
| Bellevue Group AG | 560,000 | $41.0m | 0.9% |
| Saturn V Capital Management LP | 524,730 | $38.4m | 5.5% |
| ARMISTICE CAPITAL, LLC | 460,000 | $33.6m | 0.4% |
| JENNISON ASSOCIATES LLC | 439,520 | $32.1m | 0.0% |