| BlackRock, Inc. | 2,985,667 | $355.1m | 0.0% |
| RTW INVESTMENTS, LP | 2,182,631 | $259.6m | 2.2% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 1,913,976 | $227.7m | 0.0% |
| Artisan Partners Limited Partnership | 1,660,307 | $197.5m | 0.3% |
| VANGUARD CAPITAL MANAGEMENT LLC | 1,463,211 | $174.0m | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 1,406,454 | $167.3m | 0.1% |
| FMR LLC | 1,191,982 | $141.8m | 0.0% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 944,517 | $112.4m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 881,899 | $104.9m | 0.0% |
| EVENTIDE ASSET MANAGEMENT, LLC | 880,338 | $104.7m | 1.4% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 866,528 | $103.1m | 0.1% |
| STATE STREET CORP | 856,517 | $101.9m | 0.0% |
| Holocene Advisors, LP | 783,636 | $93.2m | 0.2% |
| JPMORGAN CHASE & CO | 766,216 | $90.9m | 0.0% |
| Stephens Investment Management Group LLC | 693,437 | $82.5m | 0.9% |
| FULLER & THALER ASSET MANAGEMENT, INC. | 685,496 | $81.5m | 0.2% |
| BRAIDWELL LP | 654,262 | $77.8m | 2.9% |
| D. E. Shaw & Co., Inc. | 629,686 | $74.9m | 0.0% |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 561,251 | $66.8m | 0.1% |
| BLAIR WILLIAM & CO/IL | 524,690 | $62.4m | 0.2% |
| BANK OF AMERICA CORP /DE/ | 465,719 | $55.4m | 0.0% |
| Polar Capital Holdings Plc | 458,089 | $54.5m | 0.1% |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 450,865 | $53.6m | 0.0% |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 448,259 | $53.1m | 0.0% |
| GOLDMAN SACHS GROUP INC | 362,346 | $43.1m | 0.0% |