| BlackRock, Inc. | 17,788,557 | $74.9m | 0.0% |
| ARMISTICE CAPITAL, LLC | 13,932,000 | $58.7m | 0.7% |
| Sarissa Capital Management LP | 9,188,635 | $38.7m | 21.7% |
| STATE STREET CORP | 8,809,601 | $37.1m | 0.0% |
| BANK OF AMERICA CORP /DE/ | 8,683,803 | $36.6m | 0.0% |
| RENAISSANCE TECHNOLOGIES LLC | 7,993,226 | $33.7m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 6,608,508 | $27.8m | 0.0% |
| AQR CAPITAL MANAGEMENT LLC | 6,465,921 | $27.2m | 0.0% |
| ACADIAN ASSET MANAGEMENT LLC | 5,853,331 | $24.6m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 5,513,355 | $23.2m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 4,831,657 | $20.3m | 0.0% |
| TWO SIGMA INVESTMENTS, LP | 4,556,089 | $19.2m | 0.0% |
| MARSHALL WACE, LLP | 4,290,093 | $18.1m | 0.0% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 4,065,964 | $17.1m | 0.1% |
| GOLDMAN SACHS GROUP INC | 3,313,808 | $14.0m | 0.0% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 3,302,242 | $13.9m | 0.0% |
| FEDERATED HERMES, INC. | 3,231,238 | $13.6m | 0.0% |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 3,017,089 | $12.7m | 0.0% |
| DIMENSIONAL FUND ADVISORS LP | 2,522,891 | $10.6m | 0.0% |
| MACKENZIE FINANCIAL CORP | 2,367,493 | $10.0m | 0.0% |
| MORGAN STANLEY | 1,859,914 | $7.8m | 0.0% |
| Connor, Clark & Lunn Investment Management Ltd. | 1,811,714 | $7.6m | 0.0% |
| NORTHERN TRUST CORP | 1,373,974 | $5.8m | 0.0% |
| Hillsdale Investment Management Inc. | 1,250,428 | $5.3m | 0.1% |
| WELLS FARGO & COMPANY/MN | 1,206,198 | $5.1m | 0.0% |