| RA CAPITAL MANAGEMENT, L.P. | 11,189,693 | $171.9m | 1.5% |
| BlackRock, Inc. | 6,134,667 | $94.2m | 0.0% |
| Prosight Management, LP | 3,804,481 | $58.4m | 10.1% |
| STATE STREET CORP | 3,004,899 | $46.2m | 0.0% |
| FMR LLC | 2,412,825 | $37.1m | 0.0% |
| FEDERATED HERMES, INC. | 2,352,927 | $36.1m | 0.1% |
| Point72 Asset Management, L.P. | 1,993,837 | $30.6m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 1,857,351 | $28.5m | 0.0% |
| TCG Crossover Management, LLC | 1,789,617 | $27.5m | 0.7% |
| Alyeska Investment Group, L.P. | 1,647,140 | $25.3m | 0.1% |
| Nantahala Capital Management, LLC | 1,619,828 | $24.9m | 0.4% |
| WELLINGTON MANAGEMENT GROUP LLP | 1,507,360 | $23.2m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 1,330,710 | $20.4m | 0.0% |
| TWO SIGMA INVESTMENTS, LP | 1,207,250 | $18.5m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 1,204,150 | $18.5m | 0.0% |
| CITADEL ADVISORS LLC | 1,200,737 | $18.4m | 0.0% |
| ALGERT GLOBAL LLC | 1,110,889 | $17.1m | 0.2% |
| D. E. Shaw & Co., Inc. | 1,096,509 | $16.8m | 0.0% |
| GOLDMAN SACHS GROUP INC | 952,675 | $14.6m | 0.0% |
| BANK OF AMERICA CORP /DE/ | 910,460 | $14.0m | 0.0% |
| MORGAN STANLEY | 836,966 | $12.9m | 0.0% |
| Qube Research & Technologies Ltd | 702,057 | $10.8m | 0.0% |
| Squarepoint Ops LLC | 532,321 | $8.2m | 0.0% |
| ORBIMED ADVISORS LLC | 524,700 | $8.1m | 0.1% |
| MILLENNIUM MANAGEMENT LLC | 504,544 | $7.7m | 0.0% |