| Alphabet Inc. | 16,562,498 | $61.1m | 0.1% |
| BlackRock, Inc. | 9,602,041 | $35.4m | 0.0% |
| ARK Investment Management LLC | 8,348,746 | $30.8m | 0.2% |
| STATE STREET CORP | 7,576,460 | $28.0m | 0.0% |
| T. Rowe Price Investment Management, Inc. | 5,237,332 | $19.3m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 4,522,640 | $16.7m | 0.0% |
| Balyasny Asset Management L.P. | 3,969,082 | $14.6m | 0.0% |
| GOLDMAN SACHS GROUP INC | 3,430,518 | $12.7m | 0.0% |
| Casdin Capital, LLC | 3,167,175 | $11.7m | 0.6% |
| Woodline Partners LP | 3,003,904 | $11.1m | 0.0% |
| UBS Group AG | 2,794,689 | $10.3m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 2,712,446 | $10.0m | 0.0% |
| Sumitomo Mitsui Trust Group, Inc. | 2,412,984 | $8.9m | 0.0% |
| Amova Asset Management Americas, Inc. | 2,407,018 | $8.9m | 0.1% |
| CITADEL ADVISORS LLC | 2,054,543 | $7.6m | 0.0% |
| ADAR1 Capital Management, LLC | 1,997,552 | $7.4m | 0.3% |
| FMR LLC | 1,761,884 | $6.5m | 0.0% |
| TWO SIGMA INVESTMENTS, LP | 1,524,511 | $5.6m | 0.0% |
| Redmile Group, LLC | 1,389,632 | $5.1m | 0.3% |
| FARALLON CAPITAL MANAGEMENT, L.L.C. | 1,240,843 | $4.6m | 0.0% |
| Jump Financial, LLC | 1,240,429 | $4.6m | 0.0% |
| BANK OF AMERICA CORP /DE/ | 981,335 | $3.6m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 961,826 | $3.5m | 0.0% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 927,538 | $3.4m | 0.0% |
| NORTHERN TRUST CORP | 912,597 | $3.4m | 0.0% |