| Jupiter Topco LLC | 11,164,803 | $77.3m | 0.0% |
| BlackRock, Inc. | 7,426,780 | $51.4m | 0.0% |
| Squadron Capital Management LLC | 7,350,000 | $50.9m | 15.8% |
| Venrock Adviser, LLC | 6,844,305 | $47.4m | 1.4% |
| Spruce Street Capital LP | 6,391,328 | $44.2m | 8.7% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 4,763,158 | $33.0m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 4,460,210 | $30.9m | 0.0% |
| Jones Hill Capital LP | 3,655,075 | $25.3m | 5.4% |
| ORBIMED ADVISORS LLC | 3,631,195 | $25.1m | 0.5% |
| STATE STREET CORP | 2,517,550 | $17.4m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 2,492,573 | $17.3m | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 2,361,827 | $16.3m | 0.0% |
| MARSHALL WACE, LLP | 2,246,839 | $15.5m | 0.0% |
| Ikarian Capital, LLC | 2,148,359 | $14.9m | 1.6% |
| Driehaus Capital Management LLC | 2,132,053 | $14.8m | 0.1% |
| AMERIPRISE FINANCIAL INC | 1,937,972 | $13.4m | 0.0% |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,858,416 | $12.9m | 0.2% |
| Balyasny Asset Management L.P. | 1,520,688 | $10.5m | 0.0% |
| STEMPOINT CAPITAL LP | 1,460,093 | $10.1m | 1.7% |
| Commodore Capital LP | 1,425,000 | $9.9m | 0.6% |
| Polar Capital Holdings Plc | 1,340,428 | $9.3m | 0.0% |
| CITADEL ADVISORS LLC | 1,061,665 | $7.3m | 0.0% |
| Sio Capital Management, LLC | 1,003,562 | $6.9m | 1.1% |
| Opaleye Management Inc. | 935,000 | $6.5m | 0.6% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 898,198 | $6.2m | 0.0% |