| BlackRock, Inc. | 3,856,137 | $242.7m | 0.0% |
| Deep Track Capital, LP | 3,666,768 | $230.8m | 3.4% |
| RTW INVESTMENTS, LP | 3,357,059 | $211.3m | 1.8% |
| Jupiter Topco LLC | 2,808,796 | $176.8m | 0.1% |
| Paradigm Biocapital Advisors LP | 2,775,649 | $174.7m | 3.3% |
| Assenagon Asset Management S.A. | 1,894,990 | $119.3m | 0.1% |
| MORGAN STANLEY | 1,827,082 | $115.0m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 1,793,064 | $112.9m | 0.0% |
| JENNISON ASSOCIATES LLC | 1,663,655 | $104.7m | 0.1% |
| TANG CAPITAL MANAGEMENT LLC | 1,568,266 | $98.7m | 4.5% |
| MILLENNIUM MANAGEMENT LLC | 1,427,124 | $89.8m | 0.0% |
| BANK OF AMERICA CORP /DE/ | 1,193,182 | $75.1m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 1,105,689 | $69.6m | 0.0% |
| STATE STREET CORP | 1,072,951 | $67.5m | 0.0% |
| Vestal Point Capital, LP | 1,050,000 | $66.1m | 1.5% |
| Invesco Ltd. | 785,808 | $49.5m | 0.0% |
| GOLDMAN SACHS GROUP INC | 742,693 | $46.7m | 0.0% |
| Frazier Life Sciences Management, L.P. | 728,644 | $45.9m | 1.0% |
| D. E. Shaw & Co., Inc. | 710,559 | $44.7m | 0.0% |
| FMR LLC | 672,949 | $42.4m | 0.0% |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 607,272 | $38.2m | 0.1% |
| Clearbridge Investments, LLC | 549,387 | $34.6m | 0.0% |
| TORONTO DOMINION BANK | 510,253 | $32.1m | 0.0% |
| LORD, ABBETT & CO. LLC | 479,266 | $30.2m | 0.1% |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 427,008 | $26.9m | 0.0% |