| Avoro Capital Advisors LLC | 23,888,888 | $162.7m | 1.5% |
| RA CAPITAL MANAGEMENT, L.P. | 23,555,648 | $160.4m | 1.4% |
| GOLDMAN SACHS GROUP INC | 22,713,118 | $154.7m | 0.0% |
| BlackRock, Inc. | 20,691,927 | $140.9m | 0.0% |
| Vestal Point Capital, LP | 19,415,000 | $132.2m | 3.1% |
| MORGAN STANLEY | 16,487,479 | $112.3m | 0.0% |
| RTW INVESTMENTS, LP | 13,560,258 | $92.3m | 0.8% |
| FMR LLC | 13,336,413 | $90.8m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 12,478,595 | $85.0m | 0.0% |
| STATE STREET CORP | 11,421,920 | $77.8m | 0.0% |
| Siren, L.L.C. | 9,846,579 | $67.1m | 1.4% |
| Octagon Capital Advisors LP | 9,693,244 | $66.0m | 5.9% |
| GEODE CAPITAL MANAGEMENT, LLC | 6,560,394 | $44.7m | 0.0% |
| Polar Capital Holdings Plc | 5,117,133 | $34.8m | 0.1% |
| MPM BIOIMPACT LLC | 4,500,000 | $30.6m | 1.9% |
| D. E. Shaw & Co., Inc. | 4,398,652 | $30.0m | 0.0% |
| BAKER BROS. ADVISORS LP | 4,004,756 | $27.3m | 0.1% |
| WELLINGTON MANAGEMENT GROUP LLP | 3,975,605 | $27.1m | 0.0% |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 3,885,501 | $26.5m | 0.0% |
| GordonMD Global Investments LP | 723,185 | $24.5m | 11.9% |
| Casdin Capital, LLC | 3,250,000 | $22.1m | 1.1% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 3,140,009 | $21.4m | 0.0% |
| ADAR1 Capital Management, LLC | 3,040,466 | $20.7m | 0.9% |
| Pictet Asset Management Holding SA | 2,770,701 | $18.9m | 0.0% |
| Aberdeen Group plc | 2,327,152 | $15.8m | 0.0% |