| RA CAPITAL MANAGEMENT, L.P. | 12,198,625 | $389.6m | 3.4% |
| FMR LLC | 8,920,513 | $284.9m | 0.0% |
| Jupiter Topco LLC | 4,352,448 | $139.2m | 0.1% |
| Alta Partners Management Company, L.P. | 3,823,425 | $122.1m | 95.9% |
| Nextech Invest Ltd. | 3,553,585 | $113.5m | 5.4% |
| TCG Crossover Management, LLC | 3,248,980 | $103.8m | 2.5% |
| BlackRock, Inc. | 3,031,972 | $96.8m | 0.0% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,782,567 | $88.9m | 0.0% |
| STATE STREET CORP | 2,140,368 | $68.4m | 0.0% |
| Commodore Capital LP | 1,875,000 | $59.9m | 3.6% |
| Paradigm Biocapital Advisors LP | 1,828,607 | $58.4m | 1.1% |
| VANGUARD CAPITAL MANAGEMENT LLC | 1,508,447 | $48.2m | 0.0% |
| BVF INC/IL | 1,476,196 | $47.1m | 1.2% |
| 5AM Venture Management, LLC | 1,029,298 | $32.9m | 11.4% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,017,000 | $32.5m | 0.3% |
| Hood River Capital Management LLC | 1,016,775 | $32.5m | 0.2% |
| GEODE CAPITAL MANAGEMENT, LLC | 970,734 | $31.0m | 0.0% |
| Caligan Partners LP | 806,986 | $25.8m | 1.2% |
| Canaan Partners XI LLC | 750,000 | $24.0m | 18.8% |
| Siren, L.L.C. | 725,000 | $23.2m | 0.5% |
| Sio Capital Management, LLC | 695,315 | $22.2m | 3.7% |
| STEMPOINT CAPITAL LP | 632,754 | $20.2m | 3.5% |
| MARSHALL WACE, LLP | 583,133 | $18.6m | 0.0% |
| GOLDMAN SACHS GROUP INC | 463,477 | $14.8m | 0.0% |
| JENNISON ASSOCIATES LLC | 450,964 | $14.4m | 0.0% |