| RA CAPITAL MANAGEMENT, L.P. | 20,992,669 | $56.1m | 0.5% |
| Sands Capital Alternatives, LLC | 3,720,105 | $9.9m | 1.6% |
| BlackRock, Inc. | 2,490,115 | $6.6m | 0.0% |
| Alyeska Investment Group, L.P. | 2,454,754 | $6.6m | 0.0% |
| FRANKLIN RESOURCES INC | 2,305,096 | $6.2m | 0.0% |
| ADAR1 Capital Management, LLC | 2,111,334 | $5.6m | 0.3% |
| VANGUARD CAPITAL MANAGEMENT LLC | 1,672,072 | $4.5m | 0.0% |
| Knollwood Investment Advisory, LLC | 1,628,510 | $4.3m | 0.4% |
| GEODE CAPITAL MANAGEMENT, LLC | 1,141,858 | $3.0m | 0.0% |
| Ikarian Capital, LLC | 1,053,797 | $2.8m | 0.3% |
| Hudson Bay Capital Management LP | 955,000 | $2.5m | 0.0% |
| Pathstone Holdings, LLC | 859,110 | $2.3m | 0.0% |
| RENAISSANCE TECHNOLOGIES LLC | 675,025 | $1.8m | 0.0% |
| TWO SIGMA INVESTMENTS, LP | 622,882 | $1.7m | 0.0% |
| STATE STREET CORP | 600,528 | $1.6m | 0.0% |
| NORTHERN TRUST CORP | 360,744 | $963,187 | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 320,795 | $856,523 | 0.0% |
| DIMENSIONAL FUND ADVISORS LP | 291,559 | $778,969 | 0.0% |
| VANGUARD FIDUCIARY TRUST CO | 291,240 | $777,611 | 0.0% |
| BANK OF AMERICA CORP /DE/ | 274,781 | $733,665 | 0.0% |
| BOOTHBAY FUND MANAGEMENT, LLC | 273,012 | $728,942 | 0.0% |
| ACADIAN ASSET MANAGEMENT LLC | 270,338 | $718,000 | 0.0% |
| NOMURA HOLDINGS INC | 189,712 | $506,531 | 0.0% |
| GOLDMAN SACHS GROUP INC | 183,927 | $491,085 | 0.0% |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 176,171 | $470,377 | 0.0% |