| TCG Crossover Management, LLC | 6,007,834 | $800.6m | 19.2% |
| Helikon Investments Ltd | 2,787,131 | $371.4m | 11.1% |
| Darwin Global Management, Ltd. | 3,621,583 | $348.2m | 9.3% |
| Vestal Point Capital, LP | 2,349,443 | $313.1m | 7.3% |
| Jupiter Topco LLC | 1,913,933 | $255.1m | 0.1% |
| UBS Group AG | 1,844,918 | $245.9m | 0.0% |
| ADAR1 Capital Management, LLC | 1,804,703 | $240.5m | 11.0% |
| Caligan Partners LP | 1,557,924 | $207.6m | 9.8% |
| CITADEL ADVISORS LLC | 1,438,352 | $191.7m | 0.0% |
| MORGAN STANLEY | 1,432,185 | $190.9m | 0.0% |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 1,309,825 | $174.5m | 0.6% |
| RA CAPITAL MANAGEMENT, L.P. | 1,132,557 | $150.9m | 1.3% |
| NORGES BANK | 1,100,000 | $146.6m | 0.0% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,053,896 | $140.4m | 0.0% |
| Logos Global Management LP | 1,024,000 | $136.5m | 5.9% |
| Octagon Capital Advisors LP | 993,000 | $132.3m | 11.9% |
| BANK OF AMERICA CORP /DE/ | 971,439 | $129.5m | 0.0% |
| Eversept Partners, LP | 913,880 | $121.8m | 6.3% |
| GOLDMAN SACHS GROUP INC | 792,712 | $105.6m | 0.0% |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 765,332 | $102.0m | 5.6% |
| Cormorant Asset Management, LP | 675,000 | $90.0m | 4.6% |
| Boxer Capital Management, LLC | 605,000 | $80.6m | 6.1% |
| Balyasny Asset Management L.P. | 603,840 | $80.5m | 0.1% |
| Siren, L.L.C. | 576,000 | $76.8m | 1.6% |
| BlackRock, Inc. | 574,061 | $76.5m | 0.0% |