| BlackRock, Inc. | 6,455,997 | $239.6m | 0.0% |
| FARALLON CAPITAL MANAGEMENT, L.L.C. | 5,917,400 | $219.6m | 1.0% |
| STATE STREET CORP | 3,533,633 | $131.1m | 0.0% |
| Lynx1 Capital Management LP | 3,408,937 | $126.5m | 14.6% |
| D. E. Shaw & Co., Inc. | 3,107,005 | $115.3m | 0.1% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 2,898,197 | $107.6m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 2,681,845 | $99.5m | 0.0% |
| ARMISTICE CAPITAL, LLC | 2,400,000 | $89.1m | 1.1% |
| Erste Asset Management GmbH | 2,154,900 | $82.0m | 0.6% |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 2,110,809 | $78.3m | 0.1% |
| GEODE CAPITAL MANAGEMENT, LLC | 1,574,268 | $58.4m | 0.0% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,375,558 | $51.0m | 0.0% |
| ADAR1 Capital Management, LLC | 1,288,053 | $47.8m | 2.2% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 1,280,044 | $47.5m | 0.0% |
| DIMENSIONAL FUND ADVISORS LP | 1,248,738 | $46.3m | 0.0% |
| GW&K Investment Management, LLC | 1,206,615 | $44.8m | 0.3% |
| GOLDMAN SACHS GROUP INC | 1,150,932 | $42.7m | 0.0% |
| UBS Group AG | 985,831 | $36.6m | 0.0% |
| MORGAN STANLEY | 963,256 | $35.7m | 0.0% |
| Nuveen, LLC | 873,560 | $32.4m | 0.0% |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 810,530 | $30.1m | 0.0% |
| Foresite Capital Management VI LLC | 785,000 | $29.1m | 4.5% |
| CITADEL ADVISORS LLC | 732,687 | $27.2m | 0.0% |
| AQR CAPITAL MANAGEMENT LLC | 684,340 | $25.4m | 0.0% |
| Parkman Healthcare Partners LLC | 669,046 | $24.8m | 2.5% |