| AyurMaya Capital Management Company, LP | 15,139,707 | $426.0m | 100.0% |
| BlackRock, Inc. | 8,218,151 | $231.3m | 0.0% |
| FMR LLC | 6,769,170 | $190.5m | 0.0% |
| Deep Track Capital, LP | 6,348,558 | $178.6m | 2.6% |
| SAMSARA BIOCAPITAL, LLC | 6,345,219 | $178.6m | 14.7% |
| Foresite Capital Management V, LLC | 5,896,995 | $165.9m | 45.8% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 5,199,838 | $146.3m | 0.0% |
| venBio Partners LLC | 4,528,408 | $127.4m | 24.5% |
| Foresite Capital Management VI LLC | 4,247,670 | $119.5m | 18.6% |
| VANGUARD CAPITAL MANAGEMENT LLC | 4,215,703 | $118.6m | 0.0% |
| Nextech Invest Ltd. | 3,540,998 | $99.6m | 4.7% |
| Cormorant Asset Management, LP | 3,285,596 | $92.5m | 4.7% |
| Saturn V Capital Management LP | 2,915,443 | $82.0m | 11.8% |
| Octagon Capital Advisors LP | 2,830,700 | $79.7m | 7.2% |
| Jupiter Topco LLC | 2,355,122 | $66.2m | 0.0% |
| STATE STREET CORP | 2,187,266 | $61.5m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 2,168,517 | $61.0m | 0.0% |
| MPM BIOIMPACT LLC | 2,019,020 | $56.8m | 3.5% |
| BAKER BROS. ADVISORS LP | 2,012,500 | $56.6m | 0.3% |
| SR One Capital Management, LP | 1,959,896 | $55.2m | 5.3% |
| Invesco Ltd. | 1,173,518 | $33.0m | 0.0% |
| NOVO HOLDINGS A/S | 1,100,000 | $31.0m | 1.8% |
| PRINCIPAL FINANCIAL GROUP INC | 1,068,060 | $30.1m | 0.0% |
| D. E. Shaw & Co., Inc. | 968,234 | $27.2m | 0.0% |
| UBS Group AG | 951,796 | $26.8m | 0.0% |