| RA CAPITAL MANAGEMENT, L.P. | 13,011,849 | $26.9m | 0.2% |
| venBio Partners LLC | 12,884,638 | $26.7m | 5.1% |
| BlackRock, Inc. | 7,399,530 | $15.3m | 0.0% |
| Redmile Group, LLC | 7,392,504 | $15.3m | 1.0% |
| Blackstone Inc. | 6,593,543 | $13.6m | 0.0% |
| Driehaus Capital Management LLC | 6,025,240 | $12.5m | 0.1% |
| SILVERARC CAPITAL MANAGEMENT, LLC | 5,744,757 | $11.9m | 1.2% |
| TCG Crossover Management, LLC | 5,655,487 | $11.7m | 0.3% |
| VANGUARD CAPITAL MANAGEMENT LLC | 4,973,436 | $10.3m | 0.0% |
| Vivo Capital, LLC | 3,184,713 | $6.6m | 0.6% |
| MARSHALL WACE, LLP | 3,071,496 | $6.4m | 0.0% |
| 5AM Venture Management, LLC | 3,057,325 | $6.3m | 2.2% |
| Almitas Capital LLC | 2,938,431 | $6.1m | 1.5% |
| ORBIMED ADVISORS LLC | 2,866,256 | $5.9m | 0.1% |
| GEODE CAPITAL MANAGEMENT, LLC | 2,787,809 | $5.8m | 0.0% |
| TWO SIGMA INVESTMENTS, LP | 2,178,176 | $4.5m | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 1,543,594 | $3.2m | 0.0% |
| Nantahala Capital Management, LLC | 1,500,000 | $3.1m | 0.1% |
| STATE STREET CORP | 1,498,905 | $3.1m | 0.0% |
| ACADIAN ASSET MANAGEMENT LLC | 1,313,490 | $2.7m | 0.0% |
| JPMORGAN CHASE & CO | 1,044,728 | $2.3m | 0.0% |
| NORTHERN TRUST CORP | 935,669 | $1.9m | 0.0% |
| Ensign Peak Advisors, Inc | 810,297 | $1.7m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 749,229 | $1.6m | 0.0% |
| VANGUARD FIDUCIARY TRUST CO | 743,491 | $1.5m | 0.0% |