| Alpha Wave Global, LP | 3,707,757 | $97.8m | 1.6% |
| Commodore Capital LP | 2,723,196 | $71.9m | 4.3% |
| BlackRock, Inc. | 2,121,009 | $56.0m | 0.0% |
| PERCEPTIVE ADVISORS LLC | 1,609,893 | $42.5m | 0.6% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,600,000 | $42.2m | 0.1% |
| VANGUARD CAPITAL MANAGEMENT LLC | 1,389,477 | $36.7m | 0.0% |
| Spruce Street Capital LP | 1,353,047 | $35.7m | 7.0% |
| Vivo Capital, LLC | 1,208,858 | $31.9m | 2.9% |
| FRANKLIN RESOURCES INC | 1,013,307 | $26.7m | 0.0% |
| ARMISTICE CAPITAL, LLC | 864,000 | $22.8m | 0.3% |
| Affinity Asset Advisors, LLC | 850,000 | $22.4m | 1.0% |
| Vestal Point Capital, LP | 785,000 | $20.7m | 0.5% |
| STATE STREET CORP | 685,945 | $18.1m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 678,199 | $17.9m | 0.0% |
| 72 Investment Holdings, LLC | 667,778 | $17.6m | 35.3% |
| NORTHERN TRUST CORP | 632,701 | $16.7m | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 558,320 | $14.7m | 0.0% |
| Point72 Asset Management, L.P. | 502,950 | $13.3m | 0.0% |
| Venrock Adviser, LLC | 500,000 | $13.2m | 0.4% |
| Integral Health Asset Management, LLC | 500,000 | $13.2m | 0.5% |
| Driehaus Capital Management LLC | 487,576 | $12.9m | 0.1% |
| Parkman Healthcare Partners LLC | 429,035 | $11.3m | 1.2% |
| Ikarian Capital, LLC | 407,338 | $10.7m | 1.2% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 358,279 | $9.5m | 0.0% |
| ORBIMED ADVISORS LLC | 257,852 | $6.8m | 0.1% |