| MONTANOVA CAPITAL, LLC | 12,437,000 | $326.1m | 6.0% |
| BlackRock, Inc. | 10,545,466 | $276.5m | 0.0% |
| Frazier Life Sciences Management, L.P. | 9,874,511 | $258.9m | 5.6% |
| Rubric Capital Management LP | 8,271,577 | $216.9m | 2.0% |
| Polar Capital Holdings Plc | 6,606,945 | $173.2m | 0.4% |
| STATE STREET CORP | 5,822,840 | $152.7m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 4,988,756 | $130.8m | 0.0% |
| MORGAN STANLEY | 4,451,014 | $116.7m | 0.0% |
| JENNISON ASSOCIATES LLC | 4,219,058 | $110.6m | 0.1% |
| D. E. Shaw & Co., Inc. | 3,949,609 | $103.6m | 0.0% |
| UBS Group AG | 3,333,015 | $87.4m | 0.0% |
| BANK OF AMERICA CORP /DE/ | 2,987,431 | $78.3m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 2,982,446 | $78.2m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 2,429,005 | $63.7m | 0.0% |
| ORBIMED ADVISORS LLC | 2,042,000 | $53.5m | 1.0% |
| FRANKLIN RESOURCES INC | 1,930,982 | $50.6m | 0.0% |
| AMERICAN CENTURY COMPANIES INC | 1,925,031 | $50.5m | 0.0% |
| GOLDMAN SACHS GROUP INC | 1,668,367 | $43.7m | 0.0% |
| Jupiter Topco LLC | 1,410,435 | $37.0m | 0.0% |
| OBERWEIS ASSET MANAGEMENT INC/ | 1,372,941 | $36.0m | 0.7% |
| GILDER GAGNON HOWE & CO LLC | 1,313,211 | $34.4m | 0.4% |
| GW&K Investment Management, LLC | 1,288,018 | $33.8m | 0.3% |
| Pivotal bioVenture Partners Investment Advisor LLC | 1,265,283 | $33.2m | 10.8% |
| BAMCO INC /NY/ | 1,253,120 | $32.9m | 0.0% |
| CITADEL ADVISORS LLC | 1,160,014 | $30.4m | 0.0% |