| TCG Crossover Management, LLC | 9,533,333 | $67.7m | 1.6% |
| MONTANOVA CAPITAL, LLC | 7,206,217 | $51.2m | 0.9% |
| Frazier Life Sciences Management, L.P. | 7,100,000 | $50.4m | 1.1% |
| Nantahala Capital Management, LLC | 5,902,060 | $41.9m | 0.7% |
| Long Focus Capital Management, LLC | 5,119,582 | $36.3m | 0.9% |
| BlackRock, Inc. | 4,707,674 | $33.4m | 0.0% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 4,640,000 | $32.9m | 0.0% |
| Caligan Partners LP | 4,298,248 | $30.5m | 1.4% |
| VANGUARD CAPITAL MANAGEMENT LLC | 4,100,342 | $29.1m | 0.0% |
| FCPM III SERVICES B.V. | 4,053,775 | $28.8m | 3.8% |
| ORBIMED ADVISORS LLC | 3,333,333 | $23.7m | 0.4% |
| Medicxi Ventures Management (Jersey) Ltd | 3,039,892 | $21.6m | 12.2% |
| Jupiter Topco LLC | 2,500,000 | $17.8m | 0.0% |
| RA CAPITAL MANAGEMENT, L.P. | 2,500,000 | $17.8m | 0.2% |
| Balyasny Asset Management L.P. | 2,354,619 | $16.7m | 0.0% |
| FRANKLIN RESOURCES INC | 2,072,726 | $14.7m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 1,754,721 | $12.5m | 0.0% |
| Redmile Group, LLC | 1,666,667 | $11.8m | 0.8% |
| EcoR1 Capital, LLC | 1,666,667 | $11.8m | 0.6% |
| Trails Edge Capital Partners, LP | 1,443,333 | $10.2m | 1.6% |
| Foresite Capital Management VI LLC | 1,333,334 | $9.5m | 1.5% |
| STATE STREET CORP | 1,222,984 | $8.7m | 0.0% |
| Woodline Partners LP | 1,210,183 | $8.6m | 0.0% |
| Bellevue Group AG | 1,166,667 | $8.3m | 0.2% |
| Vivo Capital, LLC | 1,166,667 | $8.3m | 0.8% |