| MONTANOVA CAPITAL, LLC | 4,515,531 | $156.9m | 2.9% |
| INFINITUM ASSET MANAGEMENT, LLC | 4,438,384 | $154.2m | 15.6% |
| HHLR ADVISORS, LTD. | 3,929,117 | $136.5m | 16.4% |
| BlackRock, Inc. | 3,250,396 | $112.9m | 0.0% |
| ORBIMED ADVISORS LLC | 3,027,328 | $105.2m | 1.9% |
| FMR LLC | 2,778,959 | $96.5m | 0.0% |
| Octagon Capital Advisors LP | 1,971,054 | $68.5m | 6.2% |
| VANGUARD CAPITAL MANAGEMENT LLC | 1,774,873 | $61.7m | 0.0% |
| Sofinnova Investments, Inc. | 1,696,752 | $58.9m | 3.0% |
| STATE STREET CORP | 1,692,986 | $58.8m | 0.0% |
| Vivo Capital, LLC | 1,682,097 | $58.4m | 5.3% |
| NOVO HOLDINGS A/S | 1,500,000 | $52.1m | 3.0% |
| General Catalyst Group Management, LLC | 1,494,786 | $51.9m | 27.5% |
| Logos Global Management LP | 1,000,000 | $34.7m | 1.5% |
| GEODE CAPITAL MANAGEMENT, LLC | 972,626 | $33.8m | 0.0% |
| D. E. Shaw & Co., Inc. | 872,011 | $30.3m | 0.0% |
| GOLDMAN SACHS GROUP INC | 853,723 | $29.7m | 0.0% |
| HSG Holding Ltd | 663,308 | $23.0m | 1.9% |
| Point72 Asset Management, L.P. | 566,796 | $19.7m | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 438,664 | $15.2m | 0.0% |
| UBS Group AG | 438,594 | $15.2m | 0.0% |
| Balyasny Asset Management L.P. | 395,447 | $13.7m | 0.0% |
| AMERIPRISE FINANCIAL INC | 381,589 | $13.3m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 335,320 | $11.6m | 0.0% |
| NORTHERN TRUST CORP | 332,753 | $11.6m | 0.0% |