| EVENTIDE ASSET MANAGEMENT, LLC | 6,253,673 | $98.1m | 1.3% |
| Soleus Capital Management, L.P. | 4,393,714 | $68.8m | 2.4% |
| MORGAN STANLEY | 4,266,822 | $66.9m | 0.0% |
| Sands Capital Alternatives, LLC | 3,708,043 | $58.1m | 9.5% |
| BlackRock, Inc. | 3,340,171 | $52.3m | 0.0% |
| Point72 Asset Management, L.P. | 2,254,683 | $35.3m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 1,782,346 | $27.9m | 0.0% |
| Vestal Point Capital, LP | 1,600,000 | $25.1m | 0.6% |
| RTW INVESTMENTS, LP | 1,500,000 | $23.5m | 0.2% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,324,000 | $20.7m | 0.2% |
| Omega Fund Management, LLC | 1,316,183 | $20.6m | 11.1% |
| Eversept Partners, LP | 1,249,441 | $19.6m | 1.0% |
| Divisadero Street Capital Management, LP | 1,113,802 | $17.5m | 0.4% |
| GEODE CAPITAL MANAGEMENT, LLC | 1,073,452 | $16.8m | 0.0% |
| STATE STREET CORP | 970,192 | $15.2m | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 956,244 | $15.0m | 0.0% |
| Balyasny Asset Management L.P. | 855,682 | $13.4m | 0.0% |
| PERCEPTIVE ADVISORS LLC | 832,944 | $13.1m | 0.2% |
| JPMORGAN CHASE & CO | 703,356 | $12.0m | 0.0% |
| Bruce & Co., Inc. | 665,700 | $10.4m | 2.8% |
| FARALLON CAPITAL MANAGEMENT, L.L.C. | 595,000 | $9.3m | 0.0% |
| BANK OF AMERICA CORP /DE/ | 546,650 | $8.6m | 0.0% |
| GOLDMAN SACHS GROUP INC | 537,105 | $8.4m | 0.0% |
| Trexquant Investment LP | 494,435 | $7.7m | 0.0% |
| Tri Locum Partners LP | 493,344 | $7.7m | 1.0% |