| RA CAPITAL MANAGEMENT, L.P. | 7,255,993 | $215.4m | 1.9% |
| T. Rowe Price Investment Management, Inc. | 6,338,487 | $188.2m | 0.1% |
| Siren, L.L.C. | 5,602,970 | $166.4m | 3.4% |
| Vestal Point Capital, LP | 5,250,000 | $155.9m | 3.6% |
| Deep Track Capital, LP | 4,100,000 | $121.7m | 1.8% |
| BlackRock, Inc. | 3,848,090 | $114.2m | 0.0% |
| Jupiter Topco LLC | 3,171,015 | $94.0m | 0.0% |
| RED TREE MANAGEMENT, LLC | 3,163,517 | $93.9m | 63.8% |
| TPG GP A, LLC | 3,010,425 | $89.4m | 1.8% |
| VANGUARD CAPITAL MANAGEMENT LLC | 2,216,639 | $65.8m | 0.0% |
| STATE STREET CORP | 2,048,920 | $60.8m | 0.0% |
| FRANKLIN RESOURCES INC | 1,951,892 | $58.0m | 0.0% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,904,248 | $56.5m | 0.0% |
| FMR LLC | 1,893,070 | $56.2m | 0.0% |
| Omega Fund Management, LLC | 1,822,150 | $54.1m | 29.1% |
| GEODE CAPITAL MANAGEMENT, LLC | 1,162,635 | $34.5m | 0.0% |
| JPMORGAN CHASE & CO | 1,015,965 | $29.8m | 0.0% |
| Jones Hill Capital LP | 892,621 | $26.5m | 5.6% |
| ACORN CAPITAL ADVISORS, LLC | 643,381 | $19.1m | 5.2% |
| Aisling Capital Management LP | 568,919 | $16.9m | 3.6% |
| Palo Alto Investors LP | 550,408 | $16.3m | 2.3% |
| Rock Springs Capital Management LP | 535,286 | $15.9m | 0.8% |
| GOLDMAN SACHS GROUP INC | 520,567 | $15.5m | 0.0% |
| D. E. Shaw & Co., Inc. | 498,193 | $14.8m | 0.0% |
| DIMENSIONAL FUND ADVISORS LP | 461,724 | $13.7m | 0.0% |