| FMR LLC | 12,609,002 | $432.7m | 0.0% |
| FARALLON CAPITAL MANAGEMENT, L.L.C. | 10,236,396 | $351.3m | 1.6% |
| ARK Investment Management LLC | 10,234,862 | $351.3m | 2.3% |
| BlackRock, Inc. | 8,997,542 | $308.8m | 0.0% |
| STATE STREET CORP | 5,827,122 | $200.0m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 4,921,259 | $168.9m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 4,599,437 | $157.9m | 0.0% |
| ARCH Venture Management, LLC | 4,540,132 | $155.8m | 14.2% |
| Sumitomo Mitsui Trust Group, Inc. | 3,455,043 | $118.6m | 0.1% |
| Amova Asset Management Americas, Inc. | 3,455,043 | $118.5m | 1.5% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,415,239 | $117.2m | 0.0% |
| Kynam Capital Management, LP | 2,840,792 | $97.5m | 5.4% |
| GEODE CAPITAL MANAGEMENT, LLC | 2,596,963 | $89.1m | 0.0% |
| DIMENSIONAL FUND ADVISORS LP | 2,225,844 | $76.4m | 0.0% |
| MORGAN STANLEY | 1,950,969 | $67.0m | 0.0% |
| Contrarius Group Holdings Ltd | 1,614,538 | $55.4m | 2.6% |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,551,781 | $53.3m | 0.0% |
| TWO SIGMA INVESTMENTS, LP | 1,388,227 | $47.6m | 0.0% |
| Casdin Capital, LLC | 1,350,000 | $46.3m | 2.3% |
| GOLDMAN SACHS GROUP INC | 1,310,059 | $45.0m | 0.0% |
| Redmile Group, LLC | 1,164,259 | $40.0m | 2.7% |
| BNP PARIBAS FINANCIAL MARKETS | 1,067,883 | $36.6m | 0.0% |
| Deep Track Capital, LP | 1,000,000 | $34.3m | 0.5% |
| NORTHERN TRUST CORP | 933,481 | $32.0m | 0.0% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 885,902 | $30.4m | 0.0% |