| Darwin Global Management, Ltd. | 3,077,219 | $456.6m | 12.1% |
| Paradigm Biocapital Advisors LP | 1,232,877 | $189.8m | 3.6% |
| RTW INVESTMENTS, LP | 715,332 | $110.2m | 0.9% |
| MILLENNIUM MANAGEMENT LLC | 494,564 | $76.2m | 0.0% |
| MAVERICK CAPITAL LTD | 396,311 | $61.0m | 0.5% |
| EVENTIDE ASSET MANAGEMENT, LLC | 390,829 | $60.2m | 0.8% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 357,199 | $55.0m | 0.6% |
| Holocene Advisors, LP | 251,035 | $38.7m | 0.1% |
| Logos Global Management LP | 250,000 | $38.5m | 1.7% |
| MORGAN STANLEY | 235,071 | $36.2m | 0.0% |
| UBS Group AG | 224,989 | $34.6m | 0.0% |
| CITADEL ADVISORS LLC | 186,168 | $28.7m | 0.0% |
| GOLDMAN SACHS GROUP INC | 166,188 | $25.6m | 0.0% |
| Affinity Asset Advisors, LLC | 165,000 | $25.4m | 1.1% |
| MPM BIOIMPACT LLC | 137,208 | $21.1m | 1.3% |
| BANK OF AMERICA CORP /DE/ | 124,783 | $19.2m | 0.0% |
| Patient Square Capital LP | 110,000 | $16.9m | 2.6% |
| Duquesne Family Office LLC | 106,100 | $16.3m | 0.3% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 105,859 | $16.3m | 0.0% |
| JANE STREET GROUP, LLC | 65,801 | $10.1m | 0.0% |
| BNP PARIBAS FINANCIAL MARKETS | 57,125 | $8.8m | 0.0% |
| RENAISSANCE TECHNOLOGIES LLC | 55,763 | $8.6m | 0.0% |
| Point72 Asset Management, L.P. | 51,186 | $7.9m | 0.0% |
| Soleus Capital Management, L.P. | 50,524 | $7.8m | 0.3% |
| Trexquant Investment LP | 49,516 | $7.6m | 0.0% |