| BlackRock, Inc. | 9,494,152 | $32.4m | 0.0% |
| TCG Crossover Management, LLC | 7,915,567 | $27.0m | 0.6% |
| Commodore Capital LP | 6,336,782 | $21.6m | 1.3% |
| Avidity Partners Management LP | 6,299,999 | $21.5m | 3.4% |
| STATE STREET CORP | 6,051,771 | $20.6m | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 4,911,855 | $16.7m | 0.0% |
| Nantahala Capital Management, LLC | 4,650,900 | $15.9m | 0.3% |
| VANGUARD CAPITAL MANAGEMENT LLC | 4,436,572 | $15.1m | 0.0% |
| Affinity Asset Advisors, LLC | 4,214,582 | $14.4m | 0.6% |
| CITADEL ADVISORS LLC | 3,805,739 | $13.0m | 0.0% |
| Spruce Street Capital LP | 3,693,931 | $12.6m | 2.5% |
| Balyasny Asset Management L.P. | 3,320,224 | $11.3m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 2,458,673 | $8.4m | 0.0% |
| MORGAN STANLEY | 1,912,550 | $6.5m | 0.0% |
| GOLDMAN SACHS GROUP INC | 1,733,078 | $5.9m | 0.0% |
| Nicholson Wealth Management Group, LLC | 1,619,993 | $5.5m | 3.3% |
| TWO SIGMA INVESTMENTS, LP | 1,556,451 | $5.3m | 0.0% |
| ADAR1 Capital Management, LLC | 1,210,117 | $4.1m | 0.2% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 1,087,767 | $3.7m | 0.0% |
| DIMENSIONAL FUND ADVISORS LP | 1,074,071 | $3.7m | 0.0% |
| Yu Fan | 1,055,409 | $3.6m | 3.3% |
| Hills Bank & Trust Co | 872,200 | $3.0m | 0.1% |
| NORTHERN TRUST CORP | 791,774 | $2.7m | 0.0% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 773,262 | $2.6m | 0.0% |
| Ally Bridge Group (NY) LLC | 743,958 | $2.5m | 2.2% |