| FMR LLC | 5,691,393 | $110.7m | 0.0% |
| TPG GP A, LLC | 3,761,154 | $73.2m | 1.5% |
| RED TREE MANAGEMENT, LLC | 2,205,661 | $42.9m | 29.1% |
| BlackRock, Inc. | 1,936,093 | $37.7m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 1,130,346 | $22.0m | 0.0% |
| KCM Capital Inc | 1,125,000 | $21.9m | 3.5% |
| FEDERATED HERMES, INC. | 939,600 | $18.3m | 0.0% |
| FRANKLIN RESOURCES INC | 918,349 | $17.9m | 0.0% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 900,000 | $17.5m | 0.0% |
| Bank of New York Mellon Corp | 896,488 | $17.4m | 0.0% |
| TimesSquare Capital Management, LLC | 780,552 | $15.2m | 0.2% |
| MILLENNIUM MANAGEMENT LLC | 727,225 | $14.1m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 668,134 | $13.0m | 0.0% |
| ROYCE & ASSOCIATES LP | 605,010 | $11.8m | 0.1% |
| STATE STREET CORP | 547,035 | $10.6m | 0.0% |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 468,806 | $9.1m | 0.1% |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 389,675 | $7.6m | 0.0% |
| Redmile Group, LLC | 386,786 | $7.5m | 0.5% |
| JPMORGAN CHASE & CO | 345,152 | $6.9m | 0.0% |
| Yu Fan | 342,398 | $6.7m | 6.2% |
| PEREGRINE CAPITAL MANAGEMENT LLC | 331,413 | $6.4m | 0.2% |
| Creek Drive Management Group LLC | 300,881 | $5.9m | 2.8% |
| MORGAN STANLEY | 285,661 | $5.6m | 0.0% |
| GOLDMAN SACHS GROUP INC | 280,309 | $5.5m | 0.0% |
| ABG-WTT Global Life Science Capital Partners GP Ltd | 275,328 | $5.4m | 62.6% |