| MORGAN STANLEY | 8,867,338 | $41.4m | 0.0% |
| RA CAPITAL MANAGEMENT, L.P. | 8,000,000 | $37.4m | 0.3% |
| BlackRock, Inc. | 7,896,718 | $36.9m | 0.0% |
| Lynx1 Capital Management LP | 7,326,691 | $34.2m | 4.0% |
| Squadron Capital Management LLC | 7,200,000 | $33.6m | 10.4% |
| Bain Capital Life Sciences Investors, LLC | 7,171,910 | $33.5m | 2.0% |
| JPMORGAN CHASE & CO | 4,747,424 | $20.7m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 4,417,731 | $20.6m | 0.0% |
| CITADEL ADVISORS LLC | 4,187,580 | $19.6m | 0.0% |
| GOLDMAN SACHS GROUP INC | 3,530,991 | $16.5m | 0.0% |
| WASATCH ADVISORS LP | 3,522,644 | $16.5m | 0.1% |
| TWO SIGMA INVESTMENTS, LP | 3,469,707 | $16.2m | 0.0% |
| Soleus Capital Management, L.P. | 3,377,981 | $15.8m | 0.5% |
| SILVERARC CAPITAL MANAGEMENT, LLC | 3,032,060 | $14.2m | 1.5% |
| BANK OF AMERICA CORP /DE/ | 2,656,359 | $12.4m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 2,522,163 | $11.8m | 0.0% |
| Ikarian Capital, LLC | 2,433,000 | $11.4m | 1.2% |
| STATE STREET CORP | 2,115,621 | $9.9m | 0.0% |
| ACADIAN ASSET MANAGEMENT LLC | 1,806,199 | $8.4m | 0.0% |
| Candriam S.C.A. | 1,796,937 | $8.4m | 0.0% |
| D. E. Shaw & Co., Inc. | 1,740,989 | $8.1m | 0.0% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,732,210 | $8.1m | 0.0% |
| Patient Square Capital LP | 1,608,815 | $7.5m | 1.2% |
| HighVista Strategies LLC | 1,348,136 | $6.3m | 1.4% |
| RENAISSANCE TECHNOLOGIES LLC | 1,189,828 | $5.6m | 0.0% |