| BlackRock, Inc. | 4,814,709 | $137.2m | 0.0% |
| STATE STREET CORP | 2,468,858 | $70.4m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 2,197,475 | $62.6m | 0.0% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,997,618 | $56.9m | 0.6% |
| ARK Investment Management LLC | 1,953,531 | $55.7m | 0.4% |
| Boston Partners | 1,937,601 | $55.2m | 0.0% |
| BAMCO INC /NY/ | 1,937,326 | $55.2m | 0.1% |
| GAGNON SECURITIES LLC | 1,770,735 | $50.5m | 9.7% |
| Chevy Chase Trust Holdings, LLC | 1,437,416 | $41.0m | 0.1% |
| GEODE CAPITAL MANAGEMENT, LLC | 1,328,037 | $37.9m | 0.0% |
| Ophir Asset Management Pty Ltd | 1,264,809 | $36.0m | 3.0% |
| RENAISSANCE TECHNOLOGIES LLC | 1,242,959 | $35.4m | 0.0% |
| BRAIDWELL LP | 1,220,602 | $34.8m | 1.3% |
| First Eagle Investment Management, LLC | 1,196,994 | $34.1m | 0.0% |
| Sumitomo Mitsui Trust Group, Inc. | 1,191,630 | $34.0m | 0.0% |
| Blue Water Life Science Advisors, LP | 1,190,000 | $33.9m | 21.4% |
| Amova Asset Management Americas, Inc. | 1,188,075 | $33.8m | 0.4% |
| DIMENSIONAL FUND ADVISORS LP | 1,181,077 | $33.7m | 0.0% |
| D. E. Shaw & Co., Inc. | 1,137,660 | $32.4m | 0.0% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 995,669 | $28.4m | 0.1% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 989,529 | $28.2m | 0.0% |
| MORGAN STANLEY | 774,299 | $22.1m | 0.0% |
| Divisadero Street Capital Management, LP | 700,938 | $20.0m | 0.5% |
| GOLDMAN SACHS GROUP INC | 699,993 | $19.9m | 0.0% |
| Portolan Capital Management, LLC | 684,805 | $19.5m | 0.7% |