| RTW INVESTMENTS, LP | 8,514,590 | $605.0m | 5.2% |
| T. Rowe Price Investment Management, Inc. | 6,616,899 | $470.1m | 0.3% |
| Decheng Capital LLC | 6,371,669 | $452.7m | 61.9% |
| BlackRock, Inc. | 6,256,288 | $444.5m | 0.0% |
| WELLINGTON MANAGEMENT GROUP LLP | 5,324,751 | $378.3m | 0.1% |
| FMR LLC | 4,161,493 | $295.7m | 0.0% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,805,010 | $270.3m | 0.0% |
| TCG Crossover Management, LLC | 3,670,206 | $260.8m | 6.3% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 3,465,197 | $246.2m | 0.0% |
| STATE STREET CORP | 3,437,590 | $244.2m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 3,316,793 | $235.7m | 0.0% |
| Foresite Capital Management VI LLC | 2,369,574 | $168.4m | 26.2% |
| GEODE CAPITAL MANAGEMENT, LLC | 2,153,277 | $153.0m | 0.0% |
| Seven Fleet Capital Management LP | 1,886,236 | $134.0m | 22.1% |
| EcoR1 Capital, LLC | 1,494,300 | $106.2m | 5.2% |
| DV Trading LLC | 1,439,393 | $102.3m | 3.4% |
| Avidity Partners Management LP | 1,398,948 | $99.4m | 15.9% |
| FRANKLIN RESOURCES INC | 1,312,880 | $93.3m | 0.0% |
| ALLIANCEBERNSTEIN L.P. | 1,374,149 | $93.0m | 0.0% |
| MORGAN STANLEY | 1,177,109 | $83.6m | 0.0% |
| ACORN CAPITAL ADVISORS, LLC | 1,131,500 | $80.4m | 21.9% |
| Foresite Capital Management V, LLC | 1,079,050 | $76.7m | 21.2% |
| Logos Global Management LP | 1,000,000 | $71.0m | 3.1% |
| BANK OF AMERICA CORP /DE/ | 984,918 | $70.0m | 0.0% |
| UBS Group AG | 977,695 | $69.5m | 0.0% |