| Deep Track Capital, LP | 12,161,496 | $172.1m | 2.5% |
| RTW INVESTMENTS, LP | 10,700,974 | $151.4m | 1.3% |
| BIT Capital GmbH | 6,348,797 | $89.8m | 2.7% |
| TANG CAPITAL MANAGEMENT LLC | 5,000,000 | $70.8m | 3.2% |
| TWO SIGMA INVESTMENTS, LP | 4,470,485 | $63.3m | 0.0% |
| MARSHALL WACE, LLP | 4,328,682 | $61.3m | 0.0% |
| ARK Investment Management LLC | 3,451,965 | $48.8m | 0.3% |
| Point72 Asset Management, L.P. | 2,620,878 | $37.1m | 0.0% |
| Logos Global Management LP | 2,250,000 | $31.8m | 1.4% |
| Eagle Health Investments LP | 2,060,427 | $29.2m | 4.8% |
| BANK OF AMERICA CORP /DE/ | 2,019,348 | $28.6m | 0.0% |
| DAFNA Capital Management LLC | 2,011,952 | $28.5m | 5.4% |
| NEXTBio Capital Management LP | 1,775,759 | $25.1m | 11.6% |
| Kalehua Capital Management LLC | 1,639,384 | $23.2m | 7.4% |
| UBS Group AG | 1,482,470 | $21.0m | 0.0% |
| Aisling Capital Management LP | 1,432,336 | $20.3m | 4.3% |
| RENAISSANCE TECHNOLOGIES LLC | 1,431,889 | $20.3m | 0.0% |
| Candriam S.C.A. | 1,274,278 | $18.0m | 0.1% |
| Woodline Partners LP | 1,086,004 | $15.4m | 0.0% |
| CITADEL ADVISORS LLC | 1,004,880 | $14.2m | 0.0% |
| Jefferies Financial Group Inc. | 994,393 | $14.1m | 0.1% |
| BlackRock, Inc. | 925,391 | $13.1m | 0.0% |
| Trexquant Investment LP | 860,158 | $12.2m | 0.1% |
| MILLENNIUM MANAGEMENT LLC | 770,987 | $10.9m | 0.0% |
| Caption Management, LLC | 756,116 | $10.7m | 0.0% |