| ORBIMED ADVISORS LLC | 7,165,006 | $107.0m | 2.0% |
| BlackRock, Inc. | 7,138,811 | $106.7m | 0.0% |
| STATE STREET CORP | 4,474,091 | $66.8m | 0.0% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,789,126 | $56.6m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 3,292,710 | $49.2m | 0.0% |
| ADAMS STREET PARTNERS LLC | 3,275,616 | $48.9m | 11.1% |
| Vivo Capital, LLC | 2,805,816 | $41.9m | 3.8% |
| WELLINGTON MANAGEMENT GROUP LLP | 2,731,632 | $40.8m | 0.0% |
| PERCEPTIVE ADVISORS LLC | 2,667,441 | $39.9m | 0.6% |
| Deep Track Capital, LP | 2,491,939 | $37.2m | 0.5% |
| BRAIDWELL LP | 2,126,298 | $31.8m | 1.2% |
| GEODE CAPITAL MANAGEMENT, LLC | 1,853,659 | $27.7m | 0.0% |
| Foresite Capital Management VI LLC | 1,831,233 | $27.4m | 4.3% |
| GOLDMAN SACHS GROUP INC | 1,576,352 | $23.6m | 0.0% |
| Hood River Capital Management LLC | 1,571,805 | $23.5m | 0.2% |
| MORGAN STANLEY | 1,344,736 | $20.1m | 0.0% |
| Boxer Capital Management, LLC | 1,100,000 | $16.4m | 1.2% |
| Catalio Capital Management, LP | 1,080,888 | $16.1m | 3.0% |
| MILLENNIUM MANAGEMENT LLC | 1,047,985 | $15.7m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 814,750 | $12.2m | 0.0% |
| TWO SIGMA INVESTMENTS, LP | 785,208 | $11.7m | 0.0% |
| BANK OF AMERICA CORP /DE/ | 757,798 | $11.3m | 0.0% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 750,000 | $11.2m | 0.0% |
| Eversept Partners, LP | 747,994 | $11.2m | 0.6% |
| EMERALD ADVISERS, LLC | 685,683 | $10.2m | 0.2% |