| MONTANOVA CAPITAL, LLC | 2,841,334 | $46.6m | 0.9% |
| Jupiter Topco LLC | 2,734,836 | $44.8m | 0.0% |
| BlackRock, Inc. | 2,064,345 | $33.8m | 0.0% |
| JOHNSON & JOHNSON | 1,979,173 | $32.4m | 4.1% |
| FRANKLIN RESOURCES INC | 1,839,227 | $30.1m | 0.0% |
| Balyasny Asset Management L.P. | 1,522,793 | $25.0m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 1,321,356 | $21.7m | 0.0% |
| PERCEPTIVE ADVISORS LLC | 1,255,592 | $20.6m | 0.3% |
| FMR LLC | 1,040,130 | $17.0m | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 931,709 | $15.3m | 0.0% |
| GREAT POINT PARTNERS LLC | 921,481 | $15.1m | 2.9% |
| Longaeva Partners L.P. | 812,757 | $13.3m | 0.3% |
| Ikarian Capital, LLC | 807,874 | $13.2m | 1.4% |
| SECTORAL ASSET MANAGEMENT INC | 727,587 | $11.9m | 8.3% |
| GEODE CAPITAL MANAGEMENT, LLC | 693,188 | $11.4m | 0.0% |
| HHLR ADVISORS, LTD. | 669,337 | $11.0m | 1.3% |
| RED TREE MANAGEMENT, LLC | 638,158 | $10.5m | 7.1% |
| Versant Venture Management, LLC | 542,628 | $8.9m | 5.5% |
| GOLDMAN SACHS GROUP INC | 497,255 | $8.2m | 0.0% |
| Boxer Capital Management, LLC | 494,000 | $8.1m | 0.6% |
| STATE STREET CORP | 425,902 | $7.0m | 0.0% |
| CITADEL ADVISORS LLC | 396,354 | $6.5m | 0.0% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 328,000 | $5.4m | 0.0% |
| SILVERARC CAPITAL MANAGEMENT, LLC | 296,135 | $4.9m | 0.5% |
| ADAR1 Capital Management, LLC | 278,961 | $4.6m | 0.2% |