| BlackRock, Inc. | 20,094,362 | $1.7bn | 0.0% |
| T. Rowe Price Investment Management, Inc. | 18,718,498 | $1.6bn | 1.0% |
| WELLINGTON MANAGEMENT GROUP LLP | 6,931,770 | $590.5m | 0.1% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 6,711,799 | $571.8m | 0.0% |
| STATE STREET CORP | 6,494,233 | $553.2m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 6,117,515 | $521.2m | 0.0% |
| FMR LLC | 5,031,782 | $428.7m | 0.0% |
| Avoro Capital Advisors LLC | 4,999,999 | $425.9m | 3.8% |
| BANK OF AMERICA CORP /DE/ | 4,635,709 | $394.9m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 3,712,501 | $316.3m | 0.0% |
| RTW INVESTMENTS, LP | 2,862,003 | $243.8m | 2.1% |
| Polar Capital Holdings Plc | 2,253,649 | $192.0m | 0.5% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,958,946 | $166.9m | 0.0% |
| GOLDMAN SACHS GROUP INC | 1,761,588 | $150.1m | 0.0% |
| Capital Research Global Investors | 1,686,625 | $143.7m | 0.0% |
| NORTHERN TRUST CORP | 1,647,345 | $140.3m | 0.0% |
| JPMORGAN CHASE & CO | 1,588,895 | $139.2m | 0.0% |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 1,603,442 | $136.6m | 0.4% |
| Integral Health Asset Management, LLC | 1,600,000 | $136.3m | 5.4% |
| Point72 Asset Management, L.P. | 1,587,712 | $135.3m | 0.1% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,565,781 | $133.4m | 0.0% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,549,458 | $132.0m | 0.0% |
| MORGAN STANLEY | 1,510,318 | $128.7m | 0.0% |
| PRINCIPAL FINANCIAL GROUP INC | 1,311,664 | $111.7m | 0.1% |
| Capital International Investors | 1,305,848 | $111.2m | 0.0% |