| Jupiter Topco LLC | 1,349,107 | $94.8m | 0.0% |
| Cormorant Asset Management, LP | 900,000 | $63.2m | 3.2% |
| BlackRock, Inc. | 686,184 | $48.2m | 0.0% |
| Vivo Capital, LLC | 557,172 | $39.1m | 3.6% |
| Vestal Point Capital, LP | 545,000 | $38.3m | 0.9% |
| BRAIDWELL LP | 483,822 | $34.0m | 1.3% |
| Driehaus Capital Management LLC | 433,377 | $30.4m | 0.2% |
| Balyasny Asset Management L.P. | 345,053 | $24.2m | 0.0% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 335,000 | $23.5m | 0.0% |
| Point72 Asset Management, L.P. | 327,416 | $23.0m | 0.0% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 283,000 | $19.9m | 0.2% |
| RA CAPITAL MANAGEMENT, L.P. | 265,000 | $18.6m | 0.2% |
| Parkman Healthcare Partners LLC | 205,053 | $14.4m | 1.5% |
| MPM BIOIMPACT LLC | 202,114 | $14.2m | 0.9% |
| WELLINGTON MANAGEMENT GROUP LLP | 171,315 | $12.0m | 0.0% |
| GOLDMAN SACHS GROUP INC | 133,689 | $9.4m | 0.0% |
| EVENTIDE ASSET MANAGEMENT, LLC | 130,013 | $9.1m | 0.1% |
| STATE STREET CORP | 122,178 | $8.6m | 0.0% |
| SEVEN GRAND MANAGERS, LLC | 120,000 | $8.4m | 0.3% |
| GREAT POINT PARTNERS LLC | 109,603 | $7.7m | 1.5% |
| GEODE CAPITAL MANAGEMENT, LLC | 104,146 | $7.3m | 0.0% |
| ORBIMED ADVISORS LLC | 93,000 | $6.5m | 0.1% |
| ACUTA CAPITAL PARTNERS, LLC | 92,745 | $6.5m | 4.5% |
| Ikarian Capital, LLC | 88,951 | $6.2m | 0.7% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 80,060 | $5.6m | 0.0% |