| SR One Capital Management, LP | 6,526,476 | $94.4m | 9.1% |
| Logos Global Management LP | 3,000,000 | $43.4m | 1.9% |
| BAKER BROS. ADVISORS LP | 2,678,430 | $38.8m | 0.2% |
| Driehaus Capital Management LLC | 2,661,115 | $38.5m | 0.2% |
| BlackRock, Inc. | 2,660,024 | $38.5m | 0.0% |
| Point72 Asset Management, L.P. | 2,366,453 | $34.2m | 0.0% |
| Trails Edge Capital Partners, LP | 2,001,282 | $29.0m | 4.6% |
| Frazier Life Sciences Management, L.P. | 1,809,854 | $26.2m | 0.6% |
| Vivo Capital, LLC | 1,612,903 | $23.3m | 2.1% |
| VANGUARD CAPITAL MANAGEMENT LLC | 1,571,022 | $22.7m | 0.0% |
| Caption Management, LLC | 1,118,098 | $16.2m | 0.1% |
| Almitas Capital LLC | 1,026,893 | $14.9m | 3.6% |
| GEODE CAPITAL MANAGEMENT, LLC | 958,417 | $13.9m | 0.0% |
| Sofinnova Investments, Inc. | 865,135 | $12.5m | 0.6% |
| FMR LLC | 776,462 | $11.2m | 0.0% |
| MORGAN STANLEY | 765,425 | $11.1m | 0.0% |
| STATE STREET CORP | 736,221 | $10.7m | 0.0% |
| Woodline Partners LP | 700,354 | $10.1m | 0.0% |
| DIMENSIONAL FUND ADVISORS LP | 694,743 | $10.1m | 0.0% |
| GOLDMAN SACHS GROUP INC | 656,584 | $9.5m | 0.0% |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 565,597 | $8.2m | 0.0% |
| ACADIAN ASSET MANAGEMENT LLC | 537,479 | $7.8m | 0.0% |
| Siren, L.L.C. | 523,212 | $7.6m | 0.2% |
| Qube Research & Technologies Ltd | 437,079 | $6.3m | 0.0% |
| RENAISSANCE TECHNOLOGIES LLC | 387,913 | $5.6m | 0.0% |