| MONTANOVA CAPITAL, LLC | 8,296,375 | $118.6m | 2.2% |
| BlackRock, Inc. | 7,463,197 | $106.7m | 0.0% |
| Cormorant Asset Management, LP | 7,000,000 | $100.1m | 5.1% |
| FEDERATED HERMES, INC. | 5,681,052 | $81.2m | 0.1% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 4,827,792 | $69.0m | 0.1% |
| FRANKLIN RESOURCES INC | 4,807,078 | $68.7m | 0.0% |
| Commodore Capital LP | 4,600,000 | $65.8m | 3.9% |
| Jupiter Topco LLC | 3,770,381 | $53.9m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 3,630,252 | $51.9m | 0.0% |
| Paradigm Biocapital Advisors LP | 2,890,397 | $41.3m | 0.8% |
| STATE STREET CORP | 2,357,545 | $33.7m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 2,062,390 | $29.5m | 0.0% |
| Aberdeen Group plc | 2,008,802 | $28.7m | 0.0% |
| CITADEL ADVISORS LLC | 1,977,610 | $28.3m | 0.0% |
| Balyasny Asset Management L.P. | 1,812,358 | $25.9m | 0.0% |
| Parkman Healthcare Partners LLC | 1,288,163 | $18.4m | 1.9% |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,245,583 | $17.8m | 0.2% |
| TWO SIGMA INVESTMENTS, LP | 1,181,143 | $16.9m | 0.0% |
| Essex Woodlands Management, Inc. | 1,084,857 | $15.5m | 6.1% |
| ORBIMED ADVISORS LLC | 1,069,147 | $15.3m | 0.3% |
| 5AM Venture Management, LLC | 1,050,000 | $15.0m | 5.2% |
| Rosalind Advisors, Inc. | 988,230 | $14.1m | 5.2% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 971,014 | $13.9m | 0.0% |
| AMERIPRISE FINANCIAL INC | 848,410 | $12.1m | 0.0% |
| DIMENSIONAL FUND ADVISORS LP | 841,746 | $12.0m | 0.0% |