| Redmile Group, LLC | 12,872,946 | $34.8m | 2.3% |
| BlackRock, Inc. | 7,298,895 | $19.7m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 4,545,893 | $12.3m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 4,445,536 | $12.0m | 0.0% |
| ACADIAN ASSET MANAGEMENT LLC | 4,351,250 | $11.7m | 0.0% |
| AQR CAPITAL MANAGEMENT LLC | 3,837,229 | $10.4m | 0.0% |
| TWO SIGMA INVESTMENTS, LP | 3,589,863 | $9.7m | 0.0% |
| JOHNSON & JOHNSON | 3,379,064 | $9.1m | 1.1% |
| RENAISSANCE TECHNOLOGIES LLC | 2,983,268 | $8.1m | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 2,433,978 | $6.6m | 0.0% |
| GOLDMAN SACHS GROUP INC | 2,049,187 | $5.5m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 1,322,013 | $3.6m | 0.0% |
| T. Rowe Price Investment Management, Inc. | 1,080,320 | $2.9m | 0.0% |
| JANE STREET GROUP, LLC | 1,027,007 | $2.8m | 0.0% |
| CITADEL ADVISORS LLC | 993,308 | $2.7m | 0.0% |
| Bruce & Co., Inc. | 989,188 | $2.7m | 0.7% |
| MORGAN STANLEY | 694,580 | $1.9m | 0.0% |
| VANGUARD FIDUCIARY TRUST CO | 640,428 | $1.7m | 0.0% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 610,949 | $1.6m | 0.0% |
| UBS Group AG | 590,178 | $1.6m | 0.0% |
| Qube Research & Technologies Ltd | 578,150 | $1.6m | 0.0% |
| Connor, Clark & Lunn Investment Management Ltd. | 574,995 | $1.6m | 0.0% |
| STATE STREET CORP | 558,928 | $1.5m | 0.0% |
| DAFNA Capital Management LLC | 525,000 | $1.4m | 0.3% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 511,050 | $1.4m | 0.0% |