| BlackRock, Inc. | 49,115,571 | $62.9m | 0.0% |
| RA CAPITAL MANAGEMENT, L.P. | 42,809,751 | $54.8m | 0.5% |
| Soleus Capital Management, L.P. | 42,808,659 | $54.8m | 1.9% |
| STATE STREET CORP | 35,856,671 | $45.9m | 0.0% |
| CITADEL ADVISORS LLC | 29,038,928 | $37.2m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 27,250,215 | $34.9m | 0.0% |
| Nantahala Capital Management, LLC | 24,450,000 | $31.3m | 0.5% |
| Clearbridge Investments, LLC | 19,648,853 | $25.2m | 0.0% |
| Eversept Partners, LP | 18,717,422 | $24.0m | 1.2% |
| GOLDMAN SACHS GROUP INC | 16,633,368 | $21.3m | 0.0% |
| GEODE CAPITAL MANAGEMENT, LLC | 14,555,954 | $18.6m | 0.0% |
| MORGAN STANLEY | 12,945,431 | $16.6m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 10,812,598 | $13.8m | 0.0% |
| Vivo Capital, LLC | 8,671,797 | $11.1m | 1.0% |
| MILLENNIUM MANAGEMENT LLC | 8,112,267 | $10.4m | 0.0% |
| Kynam Capital Management, LP | 6,836,318 | $8.8m | 0.5% |
| Candriam S.C.A. | 5,589,182 | $7.1m | 0.0% |
| FMR LLC | 5,502,807 | $7.0m | 0.0% |
| Pale Fire Capital SE | 5,307,204 | $6.8m | 0.5% |
| NORTHERN TRUST CORP | 5,032,212 | $6.4m | 0.0% |
| UBS Group AG | 4,896,096 | $6.3m | 0.0% |
| RENAISSANCE TECHNOLOGIES LLC | 4,579,000 | $5.9m | 0.0% |
| SEGALL BRYANT & HAMILL, LLC | 4,485,554 | $5.7m | 0.1% |
| TWO SIGMA INVESTMENTS, LP | 4,308,013 | $5.5m | 0.0% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 4,284,662 | $5.5m | 0.0% |