| Paradigm Biocapital Advisors LP | 13,133,131 | $360.8m | 6.8% |
| Orbis Allan Gray Ltd | 11,368,161 | $312.3m | 1.1% |
| ALLIANCEBERNSTEIN L.P. | 8,644,877 | $231.9m | 0.1% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 6,865,000 | $188.6m | 2.0% |
| Deep Track Capital, LP | 5,650,000 | $155.2m | 2.3% |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 4,975,324 | $136.7m | 0.1% |
| BlackRock, Inc. | 4,671,252 | $128.3m | 0.0% |
| Sofinnova Investments, Inc. | 4,045,215 | $111.1m | 5.7% |
| RENAISSANCE TECHNOLOGIES LLC | 3,517,850 | $96.6m | 0.1% |
| TWO SIGMA INVESTMENTS, LP | 3,506,843 | $96.3m | 0.1% |
| Harding Loevner LP | 3,086,318 | $86.9m | 0.8% |
| FIRST TRUST ADVISORS LP | 2,756,522 | $75.7m | 0.0% |
| CITADEL ADVISORS LLC | 2,475,991 | $68.0m | 0.0% |
| Qube Research & Technologies Ltd | 1,689,284 | $46.4m | 0.0% |
| MORGAN STANLEY | 1,630,161 | $44.8m | 0.0% |
| FEDERATED HERMES, INC. | 1,449,376 | $39.8m | 0.1% |
| GOLDMAN SACHS GROUP INC | 1,279,231 | $35.1m | 0.0% |
| FRANKLIN RESOURCES INC | 1,202,923 | $33.0m | 0.0% |
| Pictet Asset Management Holding SA | 1,065,927 | $29.3m | 0.0% |
| UBS Group AG | 961,053 | $26.4m | 0.0% |
| Perpetual Ltd | 919,048 | $25.2m | 0.4% |
| NORTHERN TRUST CORP | 916,600 | $25.2m | 0.0% |
| MILLENNIUM MANAGEMENT LLC | 910,604 | $25.0m | 0.0% |
| Russell Investments Group, Ltd. | 883,430 | $24.3m | 0.0% |
| ENVESTNET ASSET MANAGEMENT INC | 829,687 | $22.8m | 0.0% |