| BlackRock, Inc. | 7,101,965 | $258.6m | 0.0% |
| FMR LLC | 3,574,115 | $130.1m | 0.0% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 2,880,489 | $104.9m | 0.0% |
| AMERICAN CENTURY COMPANIES INC | 2,539,512 | $92.5m | 0.0% |
| DIMENSIONAL FUND ADVISORS LP | 2,393,588 | $87.1m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 2,105,053 | $76.6m | 0.0% |
| LSV ASSET MANAGEMENT | 2,061,242 | $75.0m | 0.1% |
| STATE STREET CORP | 1,859,322 | $67.7m | 0.0% |
| ARMISTICE CAPITAL, LLC | 1,564,000 | $56.9m | 0.7% |
| GEODE CAPITAL MANAGEMENT, LLC | 1,442,649 | $52.5m | 0.0% |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 1,312,550 | $47.8m | 0.0% |
| RENAISSANCE TECHNOLOGIES LLC | 1,195,371 | $43.5m | 0.1% |
| TWO SIGMA INVESTMENTS, LP | 959,136 | $34.9m | 0.0% |
| AQR CAPITAL MANAGEMENT LLC | 934,326 | $34.0m | 0.0% |
| SG Americas Securities, LLC | 882,720 | $32.1m | 0.0% |
| Valor Management LLC | 818,013 | $29.8m | 0.0% |
| MORGAN STANLEY | 733,684 | $26.7m | 0.0% |
| UBS Group AG | 602,990 | $22.0m | 0.0% |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 551,075 | $20.1m | 0.0% |
| Invesco Ltd. | 528,520 | $19.2m | 0.0% |
| JPMORGAN CHASE & CO | 514,085 | $18.2m | 0.0% |
| venBio Partners LLC | 472,194 | $17.2m | 3.3% |
| NORTHERN TRUST CORP | 471,221 | $17.2m | 0.0% |
| BNP PARIBAS FINANCIAL MARKETS | 438,302 | $16.0m | 0.0% |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 423,824 | $15.4m | 0.0% |