| FMR LLC | 14,109,431 | $525.9m | 0.0% |
| BlackRock, Inc. | 8,893,260 | $331.5m | 0.0% |
| Jupiter Topco LLC | 8,579,881 | $319.7m | 0.1% |
| Capital Research Global Investors | 5,344,701 | $199.2m | 0.0% |
| BAKER BROS. ADVISORS LP | 5,010,030 | $186.7m | 0.9% |
| STATE STREET CORP | 4,548,911 | $169.5m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 4,132,646 | $154.0m | 0.0% |
| Logos Global Management LP | 3,000,000 | $111.8m | 4.8% |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 2,715,391 | $101.2m | 0.1% |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2,714,503 | $101.2m | 1.1% |
| GEODE CAPITAL MANAGEMENT, LLC | 2,425,602 | $90.4m | 0.0% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,207,451 | $82.3m | 0.0% |
| MORGAN STANLEY | 1,931,491 | $72.0m | 0.0% |
| DIMENSIONAL FUND ADVISORS LP | 1,661,281 | $61.9m | 0.0% |
| ALLIANCEBERNSTEIN L.P. | 1,627,521 | $54.2m | 0.0% |
| Fiera Capital Corp | 1,445,885 | $53.9m | 0.2% |
| FEDERATED HERMES, INC. | 1,431,630 | $53.4m | 0.1% |
| GSK plc | 1,333,333 | $49.7m | 8.3% |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | 1,269,889 | $47.3m | 0.0% |
| GOLDMAN SACHS GROUP INC | 1,231,614 | $45.9m | 0.0% |
| Candriam S.C.A. | 1,092,301 | $40.7m | 0.2% |
| BANK OF AMERICA CORP /DE/ | 1,026,143 | $38.2m | 0.0% |
| Sofinnova Investments, Inc. | 925,119 | $34.5m | 1.8% |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 891,608 | $33.2m | 0.0% |
| Fisher Asset Management, LLC | 851,306 | $31.7m | 0.0% |