| FMR LLC | 16,186,469 | $623.7m | 0.0% |
| Deep Track Capital, LP | 9,341,151 | $359.9m | 5.2% |
| BlackRock, Inc. | 7,180,897 | $276.7m | 0.0% |
| FARALLON CAPITAL MANAGEMENT, L.L.C. | 5,805,000 | $223.7m | 1.0% |
| BAKER BROS. ADVISORS LP | 5,435,220 | $209.4m | 1.0% |
| STATE STREET CORP | 4,617,005 | $177.9m | 0.0% |
| MORGAN STANLEY | 4,534,833 | $174.7m | 0.0% |
| TCG Crossover Management, LLC | 4,457,988 | $171.8m | 4.1% |
| VANGUARD PORTFOLIO MANAGEMENT LLC | 3,910,509 | $150.7m | 0.0% |
| VANGUARD CAPITAL MANAGEMENT LLC | 3,638,681 | $140.2m | 0.0% |
| JENNISON ASSOCIATES LLC | 3,310,238 | $127.5m | 0.1% |
| RTW INVESTMENTS, LP | 3,177,849 | $122.4m | 1.0% |
| Two Seas Capital LP | 3,148,505 | $121.3m | 2.4% |
| ADAR1 Capital Management, LLC | 2,330,716 | $89.8m | 4.1% |
| GEODE CAPITAL MANAGEMENT, LLC | 2,234,602 | $86.1m | 0.0% |
| T. Rowe Price Investment Management, Inc. | 2,222,101 | $85.6m | 0.1% |
| Woodline Partners LP | 1,975,869 | $76.1m | 0.2% |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,829,210 | $70.5m | 0.0% |
| GOLDMAN SACHS GROUP INC | 1,751,183 | $67.5m | 0.0% |
| ARMISTICE CAPITAL, LLC | 1,736,000 | $66.9m | 0.8% |
| Alpine Global Management, LLC | 1,375,000 | $53.0m | 8.6% |
| PERCEPTIVE ADVISORS LLC | 1,357,383 | $52.3m | 0.8% |
| D. E. Shaw & Co., Inc. | 1,240,654 | $47.8m | 0.0% |
| BANK OF AMERICA CORP /DE/ | 1,181,452 | $45.5m | 0.0% |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,022,513 | $39.4m | 0.0% |